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summary Human antomy and physiology

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Vrije Universiteit Amsterdam (VU)

Samenvatting van human antomy and physiologie hoorcollege aantekeningen gecombineerd met het boek: fundamentals of anatomy and physiology. geschreven in het engels.

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Geupload op 23 oktober 2022
Aantal pagina's 23
Geschreven in 2022/2023
Type Samenvatting

physiology
anatomy
anatomie
physiologie
heart anatomy
heart physiology
respirtory system
biomedical sciences
hap
anatomy and physiology
anatomie en physiologie
human anatomy and physiologie

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Physiology of the heart
Pulmonary circulation (= only lungs) and systemic circulation (=whole
body). If there are no separate circulations, always everything low
pressure. Relaxation needed to let new blood in. contraction
following electrical stimulation of cardiomyocytes. Automation of the
heart by pacemaker cells.

Conduction
Pacemaker cells are located in SA node on top of right atrium. The
action potential in the heart goes from SA node cell to ventricular cell. They have different action
potentials (different sodium channel):

 Pacemaker cells  unstable resting potential and slow depolarization prepotential
o Sodium going in makes membrane potential go up to pass threshold  calcium
channels also open  potassium opens later and goes out again
 Ventricular cells  need a signal by reacting to environment and quick depolarization

Spread action potential
Potential goes from SA node to AV node, this gives a delay while atrial contraction takes place.
The AV bundle conducts to the bundle branches (left bundle branch is larger) and conduct to
Purkinje fibers, through moderator band to papillary muscles in right ventricle. Because of this the
papillary muscles contract before the ventricles already closing the valves. The Purkinje fibers start
contraction at the apex spreading towards the base.

Calcium entering the cell is not enough to activate the full muscle, sarcoplasmic reticulum releases
more calcium upon entering RyR (=CICR), binding calcium to myofilament initiates contraction. For
relaxation SERCA pumps calcium back in SR. ATP is used for relaxation, not contraction, if there is no
ATP only contraction.

Electrocardiogram
ECG reflects electrical differences between regions in the heart. Meaning when none of
the cells are depolarized or all of the cells are depolarized there is no signal measured.

1. P wave = begin none of cells depolarized, end all of them depolarized of SA node
2. QRS-complex = signal through AV node spreading through ventricles, ventricle
depolarization and atrial repolarization
3. T wave = repolarization of ventricles

Location of electrodes affect the way you look at the heart. Size of the heart also affects the
depolarization wave and distance of the electrodes to the heart. There are fixed pairs of
electrodes to measure in the right directions  Einthoven’s triangle.

Abnormalities
Lead one measures right to left, when there is an inversion in the heart, the ECG will show negative
spikes instead of positive. QRS – nothing – T wave does not occur in a heart attack  coronary artery
blocked and no point with all cells repolarized. Ectopic beats are an extra systole in the rhythm,
shows an extra QRS. This can be in the atria (=supraventricular) or in the ventricles (=ventricular).

,Cardiac cycle
Blood flow through the heart is determined by pressure differences. VA valves are: tricuspid (=right)
and mitral (=left).

 Passive filling = AV valves open, aorta/pulmonary valve closed
 Atrial kick = AV valves open, aorta/pulmonary valve closed
 Isovolumetric contraction = AV valves closed, aorta/pulmonary valve closed, not yet ejection
 Ejection = AV valves closed, aorta/pulmonary valve open, blood goes out
 Isovolumetric relaxation = AV valves closed, aorta/pulmonary valve closed

The pumping of the heart makes 2 sounds. The first sound is caused by closing of the tricuspid and
mitral valve because of the systole (low pressure and low frequency), Ventricular contraction. The
second sound is made by the closing of the aorta and pulmonary valves in diastole (high pressure
and high frequency), filling of ventricles. Third heart is associated with blood flowing into the
ventricles. Fourth heart sound of the atrial contraction.

Formulas
Stroke volume = end diastolic volume – end systolic volume

Ejection fraction = EDV – ESV / EDV

 EDV = end diastolic volume, determined by available filling time and venous return
 ESV = end systolic volume, determined by preload, contractility and afterload

Cardiac output (ml/min) = stroke volume X heart rate

adjustments
Affecting stroke volume can be done in 3 ways:

 Frank-starling mechanism = increased filling pressure leads to increased stroke volume
 Adrenergic stimulation = Contractility of heart muscle by sympathetic noradrenaline
 Afterload = force needed to open aortic and pulmonary valve
o Increases when blood vessels vasoconstrict
o Decreases when blood vessels vasodilate

Long term high demand of blood  hypertrophy of the ventricles, caused by exercise or pregnancy
or after myocardial infarction (same amount of work with less muscle).

Autonomic innervation
Cardiac plexus innervates with SA and AV nodes, more sympathetic fibers. Cardioacceleratory center
controls sympathetic neurons to increase heart rate. Cardioinhibitory center control
parasympathetic neurons to slow the heart rate. These centers react to changes in BP and arterial
concentrations. Without innervation the heart will beat 80 – 100 bpm, therefore mostly
parasympathetic innervation. Changing if the heart rate is done by changing ionic permeability of
cells. Heart rate determined by resting membrane potential of the SA node cells:

 Sympathetic stimulation = using noradrenaline to open sodium and calcium channels
 Parasympathetic stimulation = acetylcholine to open up potassium channels

, Lecture 2 Anatomy of the heart
From Sternal angle to the 5th intercostal space parasternal on the right and 5 th
intercostal space midclavicular on the left. The base of the heart sits at the level of the
third costal cartilage to the left. Mediastinum = area above diaphragm and below
thoracic inlet between left and right pleural cavity, from sternum to vertebrae:

 Superior mediastinum = (yellow)  vagal nerves (above), left recurrent
laryngeal nerve, phrenic nerves (supports diaphragm, to side of the heart),
sympathetic trunk (besides vertebrae).
 Inferior mediastinum
o Anterior = (green)  artery and veins thoracicae internae (next to thymus)
o Middle = blue
o Posterior = (red)  vessels (azygos vein right side  enters in vena cava superior),
esophagus, thoracic duct, nerves

pericardium
Pericardial cavity formed by pericardium  heart is pressed up against
the inside. Consist of 2 layers:

 Fibrous pericardium = outer side, collagen fibers stabilizing
heart
 Serous pericardium = inside of 2 layers
o Parietal = outside of the heart,
o Visceral = inside touching the organ, epicardium

Pericardial fluid between the serous layers forms the pericardial
cavity. Infection in the pericardium can cause pericarditis 
inflamed surfaces rubbing against each other causes friction rub
and excess pericardial fluid production. This collecting in the
cavity causes cardiac tamponade.

Heart
Brachiocephalic trunk is first split off of the aorta, later splitting
into an artery to the head and the arm. Left subclavian artery
goes to the other arm. Right ventricle is rotated to the front, the
pulmonary artery comes from this. Both atria have an auricle
(little ear) = expandable part. Coronary sulcus marks border between atria and ventricles. Anterior
and posterior interventricular sulcus mark the boundary between the ventricles. Posterior wall of
atria are smooth surfaces, the anterior wall contains pectinate muscle.

Bloodflow
From right atrium, through right ventricle to the lungs. Inferior,
superior vena cava and coronary sinus enter the atrium. Blood
goes through tricuspid valve, attached via chordae tendineae,
fibers originate at the papillary muscles from ventricle. Internal
surface of right ventricle contains trabeculae carneae = muscular
ridges  moderator band gives stimulus for contraction papillary
muscles. Blood goes through the conus arteriosus through the
pulmonary valve into the arteries.

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