Hematopoietic And Lymphoid Systems, UTHSC Fall 202
Hematopoietic and Lymphoid Systems, UTHSC Fall 202
Tentamen (uitwerkingen)
Hematopoietic and Lymphoid Systems, UTHSC Fall 2022 D2 Pathology (Answered)
8 keer bekeken 0 keer verkocht
Vak
Hematopoietic and Lymphoid Systems, UTHSC Fall 202
Instelling
Hematopoietic And Lymphoid Systems, UTHSC Fall 202
Hematopoietic and Lymphoid Systems, UTHSC Fall 2022 D2 Pathology
Anemia
• General term, indicating a decrease in red blood cell volume (hematocrit) or concentration of hemoglobin
• Usually an indication of underlying systemic disease
Anemia - Clinical Features
• Pallor of the skin or muc...
uthsc fall 2022 d2 pathology anemia • general term
indicating a decrease in red blood cell volume hematocrit or concentration of hemoglobin • usually an indicati
Geschreven voor
Hematopoietic and Lymphoid Systems, UTHSC Fall 202
Alle documenten voor dit vak (3)
Verkoper
Volgen
LectDan
Ontvangen beoordelingen
Voorbeeld van de inhoud
Hematopoietic and Lymphoid Systems, UTHSC
Fall 2022 D2 Pathology
Anemia
• General term, indicating a decrease in red blood cell volume (hematocrit) or
concentration of hemoglobin
• Usually an indication of underlying systemic disease
Anemia - Clinical Features
• Pallor of the skin or mucosa
• Brittle, spoon-shaped nails (koilonychia)
• Fatigue, dyspnea
Iron Deficiency Anemia
• Very common condition, especially in women
• Secondary to chronic blood loss, decreased dietary intake of iron (Fe), decreased
absorption of Fe
• Decreased serum Fe
• Microcytic, hypochromic anemia
Iron Deficiency Anemia - Treatment
• Iron supplementation
• Determine and treat underlying cause
• Response to treatment is usually rapid
Plummer-Vinson Syndrome
• Iron deficiency anemia in conjunction with glossitis and dysphagia
• Associated with a high incidence of oral and esophageal squamous cell carcinoma
what cancer is Plummer-Vinson Syndrome associated with?
oral and esophageal squamous cell carcinoma
Koilonychia
Spoon nails
Plummer-Vinson Syndrome - Clinical Features
• Females, 30-50
• Burning sensation of the tongue and oral mucosa
• Angular cheilitis
• Dysphagia (esophageal webs)
• Brittle nails and koilonychia
• Fatigue
Plummer-Vinson Syndrome - Treatment
• Iron supplementation
• Esophageal dilation may be necessary
• Periodic oral cancer screening
Pernicious Anemia
• Condition caused by poor absorption of cobalamin (vitamin B12, extrinsic factor),
which is necessary for normal maturation of rbc's and other cells.
• Most patients lack intrinsic factor, which is necessary for the absorption of extrinsic
factor
Pernicious Anemia - Clinical Features
, • Fatigue, weakness, headache
• Paresthesia, tingling, or numbness of the extremities
Pernicious Anemia - Oral Clinical Features
- Burning sensations of the tongue, lips, buccal mucosa
- Erythema or atrophy
Pernicious Anemia - Treatment
• Intramuscular injection of cyanocobalamin
• Rapid resolution is usually expected
• Pernicious anemia is associated with an increased risk of stomach cancer
Aplastic Anemia
• Complete failure of hematopoietic precursor (stem) cells to differentiate into all
elements of the circulation
• Most cases appear to be an immune-mediated disease caused by cytotoxic T
lymphocytes
• Unknown etiology, but environmental toxins, viruses, and drugs have been implicated
Aplastic Anemia - Clinical Features
• Fatigue, lightheadedness (secondary to erythrocyte deficiency)
• Bleeding disorders (secondary to thrombocytopenia)
• Infections (secondary to leukocytic deficiency)
Aplastic Anemia - Oral Clinical Features
- Hemorrhage, petechiae
- Pallor
- Ulcerations
- Gingival hyperplasia
Aplastic Anemia - Histology
• Acellular marrow
• Fatty infiltration
• Little inflammation associated with ulcerations
Aplastic Anemia - Diagnosis
Pancytopenia
Aplastic Anemia - Treatment
• Supportive and symptomatic
- Antibiotics
- Transfusions
- Bone marrow transplantation
why does Aplastic Anemia have a guarded prognosis?
Recurrence is common and patients are at increased risk of developing acute leukemia
Myelophthisic Anemia
• Replacement of normal marrow elements
• Secondary to malignancies, fibrosis, osteopetrosis
• Pancytopenia
• Treatment dependent upon the underlying condition
what are some extrinsic diseases that can cause Anemia Secondary to Decreased
Red Cell Survival?
Voordelen van het kopen van samenvattingen bij Stuvia op een rij:
Verzekerd van kwaliteit door reviews
Stuvia-klanten hebben meer dan 700.000 samenvattingen beoordeeld. Zo weet je zeker dat je de beste documenten koopt!
Snel en makkelijk kopen
Je betaalt supersnel en eenmalig met iDeal, creditcard of Stuvia-tegoed voor de samenvatting. Zonder lidmaatschap.
Focus op de essentie
Samenvattingen worden geschreven voor en door anderen. Daarom zijn de samenvattingen altijd betrouwbaar en actueel. Zo kom je snel tot de kern!
Veelgestelde vragen
Wat krijg ik als ik dit document koop?
Je krijgt een PDF, die direct beschikbaar is na je aankoop. Het gekochte document is altijd, overal en oneindig toegankelijk via je profiel.
Tevredenheidsgarantie: hoe werkt dat?
Onze tevredenheidsgarantie zorgt ervoor dat je altijd een studiedocument vindt dat goed bij je past. Je vult een formulier in en onze klantenservice regelt de rest.
Van wie koop ik deze samenvatting?
Stuvia is een marktplaats, je koop dit document dus niet van ons, maar van verkoper LectDan. Stuvia faciliteert de betaling aan de verkoper.
Zit ik meteen vast aan een abonnement?
Nee, je koopt alleen deze samenvatting voor €9,88. Je zit daarna nergens aan vast.
