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Summary Pathomorphology Rapid Revision Krok 1

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In this file you will find a Rapid Revision Summary by Medic Mukul for the Pathomorphology (pathological anatomy) part of Krok 1. A part of the summary is based on most frequent asked questions as well as ministery questions.

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  • 2 mei 2023
  • 8
  • 2022/2023
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Pathomophology
Rapid Revision KROK I




Minna Mamik
@ Medic Mukul

, A block Minna Mamik
in an
artary caused by blood clots
- or other substances

Embolism Fish / Meat
Appearance Sarcoma
- Air embolism - in
injection (N2 gas)
->




Gas embolism ->
Auplane/Dwes unsear ↓I
Fibzouse liposazcoma
Adipose /Fatembolism -> Facture of Bone

Thombo embolism -


Thombophlebitis Radiation -




embolism Ionizing Radiation Aart
My
ide leukemia, Chronic ↳

obstruction(
due to
pulmonary is mostcommon


of pulmonary artay & fatal fam of venous dhomboembolism (Chernobyl) Mycloid leukemia &
papillary Concino
of the
Amniotic Fluid embolism -> New ban/placenta Thyzoid -> Generate
hydrox
Tuma- Fee Radicals


Benign (-omal Malignant Non-lonizing Radiation -> Xeoderma
Pigmentosum Endonudea 1

is slow
growing >Fast
growing Helpsin DNA Repau/Problem
, is well Circumscribed
>poory Circumscribed
Stages of Cance-3

. Distinct/clear borden , not Distinct/undeanbaden T -
Tuma famation (Size and depth of invasions)
a


>Mobile >Fixed do Sounded tissue N -




Spread to Regional lymph Node (and important most

prognostic Facta)
> No Metastasis >Metastasis M-Metastasis (single imp. P.Facta)
most

4

means the progress Beast duma spread to
From one locationte !

other location Axillary &

panasdenal lymphnodes
>Glandulal
Human
Epithelium Adenoma
-
Adeno carcinoma
Keukenberg duma/Mucinous Carcinoma ->
Signetcell zing appearan
papilloma Papillary Carcinoma ↳ Metastasis from stomach to
ovary
↳malignant duma of

->
Humor of papillary surface
Mesenchyme lipoma lipids soft liposarcoma (involvement. Medulloblastoma -



benign duma of Vermis of Corbellum
/ dissul fibzions dissueS
connective dissue Basaloma - Basal epidermal
layer duma t
Bane, Landilage, ↳&R Cerebellum hemisphere
Softtissue ( Leukoplakia -> Cance of tongue
connected
by Vermis
Lymphocyte (Doesn't exist) Lymphoma / Leukemia
(B-d T-lymphocytes)
Ewing Osteosacama - Bone duma !
Melanocyte (male) Melanoma (Melanin tumal * (Union Peel appearancel
Nevus
due to melonin pigm.
SecondaryTuberculosis
can cause it
↳occurs in Redina

↳Dopa (stain) Desmoid Tuma -> Connective dissue with
Devailing CollegenFibu
⑦pul(stain)
↳ keywad;Adypical osteoblast, Numerous


pathological Mitotic figures
will
Common
Screening method -




Malignant even
devide
moe

Dap smean -> detects Corical
dysplasia (CIN) (arvical
specific Antigen-
Prostate detects prostate
anoma Hemostasis -



process that
parents & Stops Bleeding
before it spreads Keeps blood within
damaged blood vessel
&
prostate undergoes hyperplasia
hyperd leophy
Pamaryhemostasstriction of Damaged
- leads to Benign
prostatic Hyperplasia eseen
*
H ↓
Carcinogenic agent -
cause cance
plateletAdhesion to discupted Vessel Surface

Japanese
Asbestos -
lung Carcinomas Mesodhelioma
(pork)
platelet degranulation
I ->
Edema-
L↑ vasculan


platelet Aggregation
Food* Nitrosamines permeabil
In
- stomach Carcinoma - Found in smoked o

Fermented Food case of type
polycydic Azomatic Compounds -



Highly carcinogenic
C fibainogen -
usedas
linking molecule
hypersensitivity
Fa fatming of platelet
Plug (weak)
of
the amount

Benzeen
Zings

, Minna Mamik

Problems in
primary Hemostasis can cause >Sepsis (E.coli &N. Meningitis)
Disanders; Adenocarcinoma -> activates
Muain Coagulation
Immune
Thrombocytic Acute leukemia
purpura ->
Promycolytic ->
primary granules
Autoimmune production of IgG against plateletAntigen M coagulation
activate

↳ Most Common cause oftrombocytopenia kids & in
↳ lab shows:↓ Fibzinogen, platelet I



Adults.
↳ Elevated D-Dimen Best Saning test fa DIC


Secondary hemostasis -


stabilize the weak platelet plug via
Coagulation Thrombosis Pathological formation of
=
an Intravascular

Thrombin leads Cascade
Theombin blood clot (thrombin)
to I
generate ->
prevents
hemouchage 1,Fibzin hemachage ↳
Blood ↓
Fibzinogen Can occur in
artery a Vein

Protein Goss-link ↳ M.C. location is the Deep vein (DV) of leg below kre

liver / Cirhosis
I
dot
formation
yield stable platelet Fatty
Fibrin Thombus
Gross, Pathological Feature of Alcoholic liver - Soft, yellow &
Hemanthrosis Deep dissue & liver Geasy
->
bluding into muscle joint Steatosis-Faddy changes CRevensible in


stage)
Hemophilia A -> Genetic facta * deficiency
4 x-unked
-> of
RB Recessive (affects boys most) Degeneration -




(Q)
DG Q found
Fatty/Adipose Degeneration
-




-
droplets
Fat in



Hemophilia B -Genetic factor IX
deficiency (akagiseistmas Myocardial Sancoplasm
->
With Sudan-/ Black(stain)
morie
gives yellow Red colour




Haal
-




facta XI" deficiency
-




Hemophilia C->Genetic

Hyaline
Degeneration Homogenous Glassy
en




-


appearance -


Kyai

May Occue in Fibzous tissue in scous


Von Willebrand Disease (VWF) -

blood doesn't
dot
properly & Some tumos due to deposition of
↳ Genetic VII
deficiency (v.W Factal Glycopzoteins
↳ Disade (a) Zenken's
Mostcommon inherited Coagulation degeneration ->
Glassy a Wax
Treadment;Desmopiessin (ADH -


Analoguel hyaline deg.
Intracellular Accumulations -




Vitamin k
deficiency (see -




biochemistry RR) Lipid Acc.
Triglyaride->Fatty liver/steatosis
4 babies (Fat)
can't >Cholesterol
stop bleeding (inside o outside body) -> Xandhoma

chaestrolosis

Other disorders -
Heparin Atherosdosis -> Stone-lik
=




Anticoagulant densidy
Heparin Induced
Thombocytopenia
↳ arisos due to hepain
therapy Protein Acc -



tr: heparin
zemove
Russel Bodies -
Multiple Myeloma (in plasma cells)

Disseminated Intravasculan
Coagulation (DIC) Hyaline Acc-


pathological activation of Coagulation Cascade
MallayHyaline (intracellulan) -> Alcoholic liver
Disease

↳ Minodhnombi
Widespread -> Result
in Ischemia Calcium Acc->
&Infarction
>Dystrophic Calcification -> Dead dissue
↳ >Metastatic Calcification
causes Tissue
=> Thomboplastin, Snake Bite, ->
living dissue


Dagnancy/Abadion
↳ von Koss*
(specialslain)
can also lead to Septicemia, -> cart appears black
blood
poising by bacteria
↳ than Septic Shock

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