Summary of 9 chapters of the book for laboratory animal science (Chapter 1-4, chapter 8, 10, 12, 14 and 18). The other chapters will be summarized later if possible. Complete summary, no need to read the book for these chapters!
Renée Raaijmakers, s4061357 LAS Course, Radboudumc, 2-13 October 2017
Principles of Laboratory Animal Science
A contribution to the humane use and care of animals and to the quality of
experimental results
Contents
Chapter 1. Introduction ........................................................................................................................... 6
1. Laboratory animal science........................................................................................................... 6
2. History of animal use ................................................................................................................... 6
3. Animal use: species and purposes............................................................................................... 7
4. Laboratory animal science associations ...................................................................................... 7
5. Laboratory animal science and internet...................................................................................... 7
6. Russell and Burch: The Three R’s................................................................................................. 7
7. Education and training ................................................................................................................ 7
Chapter 2. Legislation and animal experimentation ............................................................................... 9
1. Introduction ................................................................................................................................. 9
2. The EC Directive........................................................................................................................... 9
3. Impact and limitations of legislation ......................................................................................... 11
Chapter 3. Biology and husbandry of laboratory animals ..................................................................... 12
1. Introduction ............................................................................................................................... 12
2. Mammals ................................................................................................................................... 12
Mice ............................................................................................................................................... 12
Rats ................................................................................................................................................ 14
Syrian hamsters ............................................................................................................................. 14
Gerbils............................................................................................................................................ 15
Guinea-pigs .................................................................................................................................... 16
Rabbits ........................................................................................................................................... 17
Monkeys ........................................................................................................................................ 18
Dogs ............................................................................................................................................... 18
Cats ................................................................................................................................................ 19
Pigs................................................................................................................................................. 20
Sheep and goats ............................................................................................................................ 21
1
, Renée Raaijmakers, s4061357 LAS Course, Radboudumc, 2-13 October 2017
3. Birds ........................................................................................................................................... 21
Introduction ................................................................................................................................... 21
Chickens......................................................................................................................................... 22
Pigeons and doves ......................................................................................................................... 22
Quails ............................................................................................................................................. 23
4. Poikilothermic vertebrates ........................................................................................................ 23
Reptiles .......................................................................................................................................... 23
Amphibians .................................................................................................................................... 24
Fish................................................................................................................................................. 24
Chapter 4. Behaviour, stress and well-being......................................................................................... 26
1. Introduction ............................................................................................................................... 26
2. Basic mechanisms...................................................................................................................... 26
Homeostasis .................................................................................................................................. 26
Phylogeny ...................................................................................................................................... 26
Learning ......................................................................................................................................... 26
Ontogeny ....................................................................................................................................... 27
3. Interaction between the animal and its environment .............................................................. 27
Predictability and controllability ................................................................................................... 27
Conflict behaviour and behavioural pathology ............................................................................. 28
The ability to cope and individual differentiation ......................................................................... 28
4. Interaction between environment and physiology ................................................................... 28
The autonomic nervous system .................................................................................................... 29
The neuroendocrine system .......................................................................................................... 29
Body temperature ......................................................................................................................... 29
5. Functional significance of physiological stress response .......................................................... 29
6. Pathophysiology ........................................................................................................................ 30
7. Well-being ................................................................................................................................. 30
8. Concluding remarks ................................................................................................................... 30
Chapter 8. Microbiological standardization .......................................................................................... 32
1. Introduction ............................................................................................................................... 32
2. Reasons for microbiological quality assurance of laboratory animals ...................................... 32
Disease and mortality in Las .......................................................................................................... 32
Interference with results of experiments...................................................................................... 32
Zoonoses........................................................................................................................................ 32
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