Summary of the course Molecular epidemiology of infectious diseases
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Biomedische beeldvorming
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Universiteit Antwerpen (UA)
This summary includes all notes taken in class on the lessons of the course Molecular epidemiology of infectious diseases of the 2nd Master Infectious and Tropical Diseases at UAntwerp. !Contains everything except the self-study on sampling!
Summary of the course Molecular
epidemiology of infectious diseases
Comprehensive Course on Molecular Epidemiology of
Infectious Diseases
● Module 1: Introduction to Molecular Epidemiology
Lesson 1: Basics of Epidemiology
The course begins by establishing a solid foundation
in epidemiology. Students delve into the historical
evolution of epidemiological principles, understanding
the significance of John Snow's work and the
development of key concepts. This lesson emphasizes
the principles of disease spread, determinants of
health, and the critical role of surveillance in public
health.
Lesson 2: Integration of Molecular Techniques
Building on traditional epidemiological methods, this
lesson introduces advanced molecular techniques.
Students gain insights into the principles of
Polymerase Chain Reaction (PCR) and DNA
sequencing. Case studies showcase the integration of
these molecular tools into epidemiological studies,
, Summary of the course Molecular
epidemiology of infectious diseases
providing a nuanced understanding of pathogen
identification and tracking.
● Module 2: Genomic Variation and Pathogen
Evolution
Lesson 1: Genomic Diversity
This module extensively covers genomic diversity
among pathogens. Students explore the mechanisms
driving genetic variations, including point mutations,
recombination, and horizontal gene transfer. Case
studies illustrate how genomic diversity contributes to
the adaptability of infectious agents, affecting disease
emergence and evolution.
Lesson 2: Evolutionary Dynamics
Understanding the evolutionary dynamics of
pathogens is crucial for predicting disease patterns.
This lesson delves into selective pressures influencing
pathogen evolution, covering topics such as
host-pathogen interactions and environmental factors.
, Summary of the course Molecular
epidemiology of infectious diseases
Students analyze the impact of zoonotic events on the
genetic makeup of infectious agents.
● Module 3: Molecular Typing Methods
Lesson 1: DNA Fingerprinting
A comprehensive exploration of molecular typing
methods is undertaken. This includes in-depth
discussions on Restriction Fragment Length
Polymorphism (RFLP), Pulse-Field Gel
Electrophoresis (PFGE), and their applications in
characterizing strains for epidemiological purposes.
Case studies highlight the use of DNA fingerprinting
in outbreak investigations and understanding
transmission routes.
Lesson 2: Next-Generation Sequencing
Students are introduced to the transformative impact
of Next-Generation Sequencing (NGS) in molecular
epidemiology. The lesson covers the principles behind
NGS technologies, their applications in whole-genome
, Summary of the course Molecular
epidemiology of infectious diseases
sequencing, and their role in unraveling the
complexity of pathogen genomes. Case studies
showcase how NGS enhances our ability to identify
outbreaks and understand pathogen evolution.
● Module 4: Disease Surveillance and Outbreak
Investigation
Lesson 1: Molecular Surveillance
This module focuses on the integration of molecular
surveillance into public health systems. Students
explore real-time data collection, the utilization of
genomics in early detection, and its role in enhancing
global disease surveillance. Case studies highlight
instances where molecular surveillance has been
pivotal in identifying and controlling infectious disease
outbreaks.
Lesson 2: Outbreak Investigation
Building on the principles of epidemiology and
molecular techniques, this lesson delves into outbreak
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