CHM 435 Exam 2
Lead Compound - Answer-A lead compound is a compound that acts as the starting point for drug design and development. It may have disadvantages such as low activity or the presence of side effects, but it acts as a starting point for the development of a better agent.
Which of ...
which of the following needs to be established bef
what is the term used for the automated in vitro t
there are several sources and methods of discoveri
Geschreven voor
CHM 435 Exam 2
CHM 435 Exam 2
CHM 435 Exam 2
Alle documenten voor dit vak (1)
Verkoper
Volgen
Gurustudy
Ontvangen beoordelingen
Voorbeeld van de inhoud
CHM 435 Exam 2
Lead Compound - Answer-A lead compound is a compound that acts as the starting point for
drug design and development. It may have disadvantages such as low activity or the presence
of side effects, but it acts as a starting point for the development of a better agent.
Which of the following needs to be established before the search for a lead compound takes
place?
A) the Pharmacophore
B) Structure-Activity relationships
C) a Bioassay
D) Patents - Answer-C
The lead compound has to have some sort of desirable biological activity, and so a bioassay to
detect that activity is required. Structure-activity relationships and the identification of a
pharmacophore are stages in the drug design process that come after the discovery of the lead
compound. Patents are taken out at a later stage once potentially useful compounds have been
designed and developed.
What is the term used for the automated in vitro testing of large numbers of compounds using
genetically modified cells?
A) Robotic Testing
B) High throughput screening
C) multiscreening
D) nanotechnology - Answer-B
As well as being automated and capable of handling large numbers of compounds, high
throughput screening (HTS) can be carried out on small scale, allowing results to be obtained
quickly and efficiently.
There are several sources and methods of discovering new compounds. Which of the following
is most likely to lead to the discovery of a complex structure quite unlike any other previously
discovered?
A) combinatorial chemistry
B) database mining
C) screening plant extracts
D) me too drugs - Answer-C
There are no preconceived ideas when screening plant extracts for active lead compounds.
Some natural products are quite bizarre in structure!
Combinatorial Chemistry - Answer-Combinatorial chemistry involves the synthesis of a large
number of compounds
using a standard synthetic route, and so the types of structures that will be
synthesised are predictable and belong to a similar family of compounds.
Database Mining - Answer-Database mining involves the computerised search of known
compounds for
particular pharmacophores.
Me-too drugs - Answer-Me-too drugs are analogues of an established drug
Voordelen van het kopen van samenvattingen bij Stuvia op een rij:
Verzekerd van kwaliteit door reviews
Stuvia-klanten hebben meer dan 700.000 samenvattingen beoordeeld. Zo weet je zeker dat je de beste documenten koopt!
Snel en makkelijk kopen
Je betaalt supersnel en eenmalig met iDeal, creditcard of Stuvia-tegoed voor de samenvatting. Zonder lidmaatschap.
Focus op de essentie
Samenvattingen worden geschreven voor en door anderen. Daarom zijn de samenvattingen altijd betrouwbaar en actueel. Zo kom je snel tot de kern!
Veelgestelde vragen
Wat krijg ik als ik dit document koop?
Je krijgt een PDF, die direct beschikbaar is na je aankoop. Het gekochte document is altijd, overal en oneindig toegankelijk via je profiel.
Tevredenheidsgarantie: hoe werkt dat?
Onze tevredenheidsgarantie zorgt ervoor dat je altijd een studiedocument vindt dat goed bij je past. Je vult een formulier in en onze klantenservice regelt de rest.
Van wie koop ik deze samenvatting?
Stuvia is een marktplaats, je koop dit document dus niet van ons, maar van verkoper Gurustudy. Stuvia faciliteert de betaling aan de verkoper.
Zit ik meteen vast aan een abonnement?
Nee, je koopt alleen deze samenvatting voor €9,47. Je zit daarna nergens aan vast.
