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BIOMATERIALS : THEINTERSECTION OF BIOLOGY AND MATE
BIOMATERIALS : THEINTERSECTION OF BIOLOGY AND MATE
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TestBank Biomaterials: The Intersection of Biology and Materials Science, 2nd ed. Temenoff and Mikos End of Chapter Problems Solutions Manual
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Biomaterials
Biomaterials: The Intersection of Biology and Materials Science, 2nd ed.
Temenoff and Mikos
End of Chapter Problems Solutions Manual
(Note that only the text of the problems and solutions have been included in this solutions
manual. For figures associated with particular problems, please see th...
BIOMATERIALS : THEINTERSECTION OF BIOLOGY AND MATE
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SOLUTIONS MANUAL
BIOMATERIALS : T HE INTERSECTION OF
BIOLOGY AND M ATERIALS S CIENCE
SECOND EDITION
J. S. Temenoff
Wallace H. Coulter Department of Biomedical Engineering
Georgia Tech and Emory University, Atlanta, GA
A. G. Mikos
Departments of Bioengineering and Chemical and Biomolecular Engineering
Rice University, Houston, TX
,
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ISBN-13: 978-0-13-463249-0
ISBN-10: 0-13-463249-4
, Biomaterials: The Intersection of Biology and Materials Science, 2nd ed.
Temenoff and Mikos
End of Chapter Problems Solutions Manual
(Note that only the text of the problems and solutions have been included in this solutions
manual. For figures associated with particular problems, please see the appropriate chapter in
the textbook.)
, Chapter 1
1.1 An artery is a flexible blood vessel that withstands various pressures regulates the flow of
blood. A common application of biomaterials is in the fabrication of a vascular stent to prevent
re-closure of arteries after angioplasty (removal of plaques that impede blood flow). In many of
these products, metals are used and formed into a “chain link” type architecture.
(a) What specific bulk and surface material properties would be required for this application?
A variety of answers are acceptable as long as properly justified, particularly relating to the idea
of flexibility (bulk mechanical property) and how the device interacts with blood (surface
physical or chemical properties).
(b) Explain why this material type and architecture were chosen in terms of the properties you
have listed above.
A variety of answers are acceptable as long as properly justified. An example: Metals can be
easily formed into complex shapes like that shown here. The chain-link architecture allows for
expansibility of the material without fracture, while providing sufficient strength to push against
the side of the blood vessel.
1.2 A current area of biomaterials research is in developing a tissue engineered bone replacement
to be placed in large bone defects. In general, this approach involves seeding bone cells on a
scaffolding material with the idea that this entire construct would be implanted into the site of
injury to replace lost bone.
(a) Would a natural or synthetic material be best for the scaffold? Justify your answer in terms of
the expected response of the body to your construct and why this material class may be better for
this application.
Either natural or synthetic materials could be acceptable answers, as long as justified using
concepts in 1.4.4.
(b) What FDA regulatory pathway would likely be involved in approval of this product?
This would likely be a combination product (device + biologic), so its main mechanism of action
would have to be determined by the FDA and then that Center would take the lead in the
regulatory process, with the other taking a secondary role.
1.3 Whether or not the biological response to a material is acceptable depends on the specific
application (see definition of biocompatibility, Section 1.1). Assume a new material shows
activation of the immune system in vivo. Discuss whether or not this result would be acceptable
for the following applications and explain your reasoning:
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