USMLE Step 1 Rapid Review
Che Gout, MR, self-mutilating behavior in a boy - Lesch-Nyhan syndrome (HGPRT deficiency, X-
linked recessive)
st pain, pericardial effusion/friction rub, persistent fever following MI - Dressler's (autoimmune
post-MI)
Achilles tendon xanthoma - Familial hypercholesterolemia
Adrenal hemorrhage, hypotension, DIC - Waterhouse-Friderichsen syndrome (meningococcemia)
Arachnodactyly, lens dislocation, aortic dissection, hyperflexible joints - Marfan's (fibrillin defect)
Athlete with polycythemia - Erythropoietin injection
Back pain, fever, night sweats, weight loss - Pott's (TB to the vertebrae)
Bilateral hilar adenopathy, uveitis - Sarcoid
Blue sclera - Osteogenesis imperfecta
Bluish line on gingiva - Burton's line - lead poisoning
Bone pain, bone enlargement, arthritis, (also increased hat size, fracture, increased alk phos) -
Paget's
Bounding pulses, diastolic hear murmur, head bobbing - Aortic regurg
Café-au-lait spots, Lisch nodules - NF (1 = optic glimoas and pheo, 2 = acoustic Schwannomas)
,Café-au-lait spots, polyostotic fibrous dysplasia, precocious puberty - McCune-Albright syndome
(G protein problem)
Calf pseudohypertrophy - Duchenne's muscular dystrophy
Cherry-red spot on macula - Tay-Sachs, Niemann-Pick, central retinal artery occlusion
Child uses arms to stand up from squat - Gower's sign (Duchenne's)
Child with fever develops red rash on face that spreads to body - Slapped cheek - B19
Chorea, dementia, caudate degeneration - Huntington's
Chronic exercise intolerance with myalgia, fatigue, painful cramps - McArdle's (muscle
phosphorylase deficiency)
Cold intolerance - Hypothyroidism
Conjugate lateral gaze palsy, horizontal diplopia - Internuclear ophthalmoplegia (MS or stroke)
Continuous machinery heart murmur - PDA
Cutaneous/dermal edema due to CT expansion - Myxedema
Dark purple skin / mouth nodules - Kaposi's sarcoma
Deep, labored breathing / hyperventilation - Kussmaul breathing, DKA
, Dermatitis, dementia, diarrhea - Pellagra (B3 / niacin deficiency)
Dilated cardiomyopathy, edema, polyneuropathy - Wet beriberi (B1 / thiamine deficiency)
Dog or cat bite resulting in infection - Pasteurella multocida (local cellulitis)
Dry eyes, dry mouth, arthritis - Sjogren's syndrome
Dysphagia (esophageal webs), glossitis (smooth tongue), iron deficiency anemia - Plummer-
Vinson syndrome
Abdominal pain, ascites, hepatomegaly, (also high D dimer, CHF without JVD) - Budd-Chiari
syndrome
Elastic skin, hypermobility of joints - Ehler-Danlos (type III collagen)
Enlarged. hard left supraclavicular node - VIrchow's node (abdominal met)
Erythroderma, lymphadenopathy, hepatosplenomegaly, atypical T cells - Sezary syndrome
(cutaneous T cell lymphoma)
Facial muscle spasm upon tapping - Chvostek's sign (hypocalcemia)
Fat, female, fertile, forty - Gallstones
Fever, chills, headache, myalgia following antibiotic treatment for syphillis - Jarisch-Herxheimer
reaction (lysis of spirochetes results in toxin release)
Fever, cough, conjunctivitis, coryza, diffuse rash, Koplick spots - Measles
