CMB2004 Exam Questions With Verified
Answers.
Are B and T lymphocytes part of the adaptive or innate immune response? - answerAdaptive
it is the immune memory evolved over time
What is the clonal selection theory? - answerImmature lymphocytes that could self find are
destroyed
Mature naive ly...
Are B and T lymphocytes part of the adaptive or innate immune response? - answer✔✔Adaptive
it is the immune memory evolved over time
What is the clonal selection theory? - answer✔✔Immature lymphocytes that could self find are
destroyed
Mature naive lymphocytes are mature until they are exposed to antigens
What are the two types of B receptor? - answer✔✔Membrane bound
And released from membrane they are known as antibodies
T cell receptors are only membrane bound and are formed of what heterodimer? -
answer✔✔Alpha and beta chains
Antibodies are formed if a light and heavy chain, what interactions are there between the two? -
answer✔✔Disulphide bridge (Hinge region)
And non covalent interactions
What forms the N terminal region of an antibody? - answer✔✔The antigen binding site of the
light and heavy chain known as the variable region
The C terminal constant region is also known as what? - answer✔✔The FC region (fragment
crystallisable)
The region containing the variable region is called FAB (fragment antigen binding)
Glycosylation of C2 modulates binding of heavy chain
The light chains are either lambda or kappa, what chromosome encodes each? -
answer✔✔Lambda = chromosome 22 - 30 V genes and 7J
Kappa = chromosome 2 - 52 V genes and 5J
There are 5 isotopes of antibody, what are they? - answer✔✔IgM, IgD, IgG, IgE, IgA
How many hyper variable loops are there in total? - answer✔✔6
What are complimentary determing regions? - answer✔✔Sections of the variable region which
bind the antigen
What is an epitope? - answer✔✔the part of an antigen molecule to which an antibody attaches
itself
Can be linear = continuous
Conformational = discontinuous
Multitalented antigen - antigen with more than one epitope
What is MHC called in humans? - answer✔✔Human Leukocyte Antigen (HLA)
Which cells present MHCI?
And MHCII? - answer✔✔I = on all nucleated cells
II = specialised immune cells
Class 1 is formed of heterodimers of alpha and B2 microglobulins what are the three types
encoded by different alpha genes? - answer✔✔HLA-A
HLA-B
HLA-C
Alpha 1 and 2 form beta sheet and the peptide binding cleft
Alpha 3 and beta 2 form ig like domains
CDc8 - stabilisation.
Class 2 is formed if heterodimers of alpha and beta chains with two transmembrane peptides
what are the three tyoes? - answer✔✔HLA-DP
HLA-DQ
HLA-DR
Alpha and beta 1 form the peptide binding cleft
CD4 aid stabilisation
Lymphocyte differentiation involves DNA being broken on purpose and what type of
recombination? - answer✔✔Non homologous end joining
What genes encode the heavy chain (TCRb) variable region ? - answer✔✔V, D and J regions
Light chain (TCRa) = V and J
Voordelen van het kopen van samenvattingen bij Stuvia op een rij:
Verzekerd van kwaliteit door reviews
Stuvia-klanten hebben meer dan 700.000 samenvattingen beoordeeld. Zo weet je zeker dat je de beste documenten koopt!
Snel en makkelijk kopen
Je betaalt supersnel en eenmalig met iDeal, creditcard of Stuvia-tegoed voor de samenvatting. Zonder lidmaatschap.
Focus op de essentie
Samenvattingen worden geschreven voor en door anderen. Daarom zijn de samenvattingen altijd betrouwbaar en actueel. Zo kom je snel tot de kern!
Veelgestelde vragen
Wat krijg ik als ik dit document koop?
Je krijgt een PDF, die direct beschikbaar is na je aankoop. Het gekochte document is altijd, overal en oneindig toegankelijk via je profiel.
Tevredenheidsgarantie: hoe werkt dat?
Onze tevredenheidsgarantie zorgt ervoor dat je altijd een studiedocument vindt dat goed bij je past. Je vult een formulier in en onze klantenservice regelt de rest.
Van wie koop ik deze samenvatting?
Stuvia is een marktplaats, je koop dit document dus niet van ons, maar van verkoper Brightstars. Stuvia faciliteert de betaling aan de verkoper.
Zit ik meteen vast aan een abonnement?
Nee, je koopt alleen deze samenvatting voor €12,28. Je zit daarna nergens aan vast.
