NBME EXAM QUESTIONS WITH VERIFIED SOLUTIONS |GRADED A+
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NBME EXAM QUESTIONS WITH VERIFIED SOLUTIONS |GRADED A+
Ethanol lead sto induction of P450 enzymes that result in increased production of NAPQI when high doses of tylenol taken.
depletin of glutathione. give NAC.
translocations - ANSWER balanced - no significant consequence unless the br...
NBME EXAM QUESTIONS WITH
VERIFIED SOLUTIONS |GRADED
A+
Ethanol lead sto induction of P450 enzymes that result in
increased production of NAPQI when high doses of tylenol taken.
depletin of glutathione. give NAC.
translocations - ANSWER balanced - no significant consequence
unless the break point affects a regulatory sequence or section of
an exam that results in reduced or absent translation of encoded
protein.
Frank Starling mechanism - ANSWER relationship between
cardiac output and LVEDV - preload.
CHF - line falls down
AVM - increased CO per this relationship
Tamponade - decreased ventricular filling but no change on this
curve
Cor pulmonale - RVF from chronic pulm HTN no change on this
curve
Restrictive cardiomyopathy - decreased compliance of ventricular
wall disatolic dysfunction and preserved LV systolic function (CO
would be preserved)
, renal autoregulation - ANSWER relatively constantly GFR
despite change sin glomerular perfusion and is mediated by
delivery of filtered sodium to macula densea in ealry DCT. in
Renal a. stenosis, there is a decreased glomerular perfusion -->
decreased filtration and decreased sodium delivery to macula
densa. COmpensates by promoting activatoin of RAASD system -
-> constriction of efferent arteriolar. Induces increased
intraglomerular pressure to maintain GFR.
Round ligament - ANSWER fibromusclar band of tissue that
extends from superolateral part of uterus where fallopian tubes
insert, passes through the inguinal canal, ends in labia majora.
remnant of gubernaculum. this is stretched in preganancy --> pain
an investigator is conducting a study of the effetcs of a newly
discovered spider venom on NM transmission. Isolated nerve
muscle prepartion is bathed in a solution containing the venom;
there is a decreased in teh end-plate potential amplitude following
stimulation of the nerve. Presence of venom does not change the
amplitude of the nerve AP or the repsosne to exogenous
acetylcholine. BLockage of which fo the following is the MOA?
- Chloride conductance
- Function of acetylocholinesterase
- Inactiavte of voltage-gated Na channels in muscle
- Insertion of AChR into muscle membrane
- Presynaptic, voltage-gated calcium channels - ANSWER
Presynaptic, voltage-gated calcium channels
decreased end-plate potential amplitude.
normallY: AP --> depolarization of terminal bouton of axon -->
presynaptic voltage-gated Ca channels consequently open and
allow calcium influx which tiggers exocytosis of ACh filled vesicle
sinto synaptic cleft.
, brief psychotic disorder - ANSWER characterized by acute onset
of one or more psychotic symptoms (delusions, hallucinations
disorganized speech, d/o behavior) lasting less that one month.
schizoaffective = 6 m/o
vasopressin is made in - ANSWER the paraventricular and
supraoptic nuclei
transformation required ____ DNA - ANSWER naked (not a/w
proteins/lipids/molecules)
Waardenburg syndrome - ANSWER syndrome of pathy
depigmentation of skin, ahir, irises, cochlear dyscuntion
AD
neural crest cells do not properly differentiare into melanoblasts
- white forelock, eyelashes, depigmented skin patches, iridic
heterochromia, sensorineural deafness, eyes may be laterally
displaced
Glucose-dependent insulinotropic peptide (GIP) - ANSWER
secreted by duodenum & jejunum (K cells), paracrine and
classical signaling to pancreas. Stimulates insulin secretion,
triggered by glucose in the duodenum.
to decreased gastric acid production and stimulate insulin release
from pancrease
RR = x per 10,000 / y per 10,000 - ANSWER RR = x/y
obese vs. non obese same drug administered - ANSWER greater
volume of distribution os takes longer ot get to therapeutic dose
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