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Penn Foster Pharmacology Questions and Answers 100% Pass What is first-pass metabolism? The process where a drug is metabolized by the liver before it reaches systemic circulation, reducing its bioavailability. What is the role of plasma protein binding in drug action? Drugs that bind...

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Penn Foster Pharmacology Questions
and Answers 100% Pass

What is first-pass metabolism?


✔✔ The process where a drug is metabolized by the liver before it reaches systemic circulation,

reducing its bioavailability.




What is the role of plasma protein binding in drug action?


✔✔ Drugs that bind to plasma proteins in the bloodstream can be temporarily inactive and are

released slowly to exert their effects.




What is meant by titration in pharmacology?


✔✔ The gradual adjustment of drug dosage to achieve the optimal therapeutic effect while

minimizing side effects.




What is the significance of a drug's therapeutic window?


✔✔ The range of drug concentrations in the blood where the drug is effective without being

toxic.




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,What are prodrugs and how do they function?


✔✔ Prodrugs are inactive drugs that become active only after undergoing metabolism within the

body.




What does receptor downregulation mean in pharmacology?


✔✔ The process where prolonged exposure to a drug decreases the number of receptors

available, reducing the drug's effectiveness.




What is pharmacogenomics?


✔✔ The study of how an individual's genetic makeup affects their response to drugs, aiming to

tailor treatments to each person.




What are dose-dependent side effects?


✔✔ Side effects that increase in severity with higher doses of a drug.




What is the purpose of a loading dose?


✔✔ To rapidly achieve therapeutic drug levels in the body, especially for drugs with a long half-

life.




2

,What does bioequivalence mean?


✔✔ A term indicating that two drug products release the same amount of active ingredient into

the bloodstream at the same rate and extent.




What is receptor desensitization?


✔✔ A phenomenon where continuous exposure to a drug leads to a decreased response from the

receptors over time.




What is pharmacokinetic tolerance?


✔✔ When the body becomes more efficient at metabolizing a drug, leading to reduced drug

levels and effectiveness.




How does food-drug interaction affect drug efficacy?


✔✔ Food can alter the absorption, metabolism, or excretion of a drug, potentially enhancing or

diminishing its therapeutic effect.




What is the difference between idiosyncratic reactions and allergic reactions to drugs?




3

, ✔✔ Idiosyncratic reactions are rare and unpredictable adverse effects that are not related to the

drug's known pharmacological action, while allergic reactions are immune-mediated responses to

the drug.




What does steady-state concentration refer to in drug administration?


✔✔ The point at which the rate of drug administration equals the rate of drug elimination,

resulting in constant drug levels in the body.




What is pharmacology?


✔✔ The study of drugs, including their origin, effects, and how they are used to treat diseases.




What is the difference between a drug's generic name and its brand name?


✔✔ The generic name is the official, non-proprietary name of the drug, while the brand name is

the trademarked name given by the manufacturer.




What is the primary purpose of a drug's pharmacokinetics?


✔✔ To study how the drug is absorbed, distributed, metabolized, and excreted in the body.




What does the term bioavailability refer to in pharmacology?

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