College aantekeningen

Aantekeningen Klinische Neuropsychologie deeltentamen 1 (2024) - UvA, Psychobiologie

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Instelling
Universiteit Van Amsterdam (UvA)

Boek
Klinische neuropsychologie

In dit document vind je mijn uitgebreide aantekeningen van de colleges van deeltentamen 1. De aantekeningen zijn in de taal waarin het college is gegeven. Als je dit document koopt in 2025 of later, kan ik natuurlijk niet garanderen dat de colleges dezelfde inhoud bevatten.

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Geupload op 21 september 2024
Aantal pagina's 126
Geschreven in 2024/2025
Type College aantekeningen
Docent(en) Joe bathelt & erwin van vliet
Bevat College 1 t/m 11 (deeltentamen 1)

knp
psychobiologie
dsm
diermodellen
anorexia
obesitas
alzheimer
dementie
genderdysforie
klinische neuropsychologie
uva
genetische ontwikkelingsstoornissen
vasculaire cognitieve stoornissen

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Inhoud
Hoorcollege 1: History of Neuropsychology (02-09) ............................................................................... 7
Leerdoelen ....................................................................................................................................... 7
Studiemateriaal ............................................................................................................................... 7
History ................................................................................................................................................. 7
Antiquity (400 BCE – 300 BCE)......................................................................................................... 8
Renaissance (1500 – 1900) .............................................................................................................. 8
19th century (1800 – WWI) .............................................................................................................. 9
20th century (1900 – 1990) .............................................................................................................. 9
Dark history ................................................................................................................................... 10
Hoorcollege 2: DSM en diermodellen (03-09) ....................................................................................... 11
Leerdoelen:........................................................................................................................................ 11
Definities........................................................................................................................................ 11
Classificatie psychiatrische stoornissen ............................................................................................. 11
DSM ............................................................................................................................................... 11
Alternatieven ................................................................................................................................. 14
Onderzoek naar hersenziektes op verschillende niveaus.............................................................. 15
Diermodellen ..................................................................................................................................... 17
Gebruik van diermodellen in onderzoek ....................................................................................... 17
Diermodel: goed model voor mens? (Artikel) ............................................................................... 17
Beperkingen diermodellen ............................................................................................................ 19
Soorten diermodellen.................................................................................................................... 19
Hoorcollege 3: Dementie (05-09) .......................................................................................................... 22
De ziekte van Alzheimer en dementie ............................................................................................... 22
Leerdoelen ..................................................................................................................................... 22
Verschijnselen / symptomen; ........................................................................................................ 22
Progressie ...................................................................................................................................... 23
Prevalentie en soorten .................................................................................................................. 23
Veranderingen in de hersenen ...................................................................................................... 23
Overige veranderingen .................................................................................................................. 25
Genetische (risico)factoren bij AD ................................................................................................. 29
Overige risicofactoren ................................................................................................................... 31
Genetica......................................................................................................................................... 31
Therapie ......................................................................................................................................... 32
Part I: Frontotemporal Dementia (FDT) ............................................................................................. 35

, Leerdoelen ..................................................................................................................................... 35
Materiaal ....................................................................................................................................... 35
FDT and variants ............................................................................................................................ 35
Diagnosis........................................................................................................................................ 36
Brain differences ............................................................................................................................ 37
Progression .................................................................................................................................... 38
Genetics ......................................................................................................................................... 38
Neuropathology............................................................................................................................. 38
Misdiagnosis and treatment .......................................................................................................... 39
Summary ....................................................................................................................................... 39
Part II: Dementia with Lewy Bodies................................................................................................... 39
Learning outcomes ........................................................................................................................ 39
Learning materials ......................................................................................................................... 40
Dementia with Lewy Bodies .......................................................................................................... 40
Prevalence ..................................................................................................................................... 40
Neuropathology............................................................................................................................. 40
Genetics ......................................................................................................................................... 40
Clinical Characteristics ................................................................................................................... 40
Treatment ...................................................................................................................................... 41
Summary ....................................................................................................................................... 41
Guess the disorder exercise (slide 44): .......................................................................................... 42
Hoorcollege 4: Eetstoornissen (06-09) .................................................................................................. 43
Anorexia Nervosa (AN) ...................................................................................................................... 43
Leerdoelen ..................................................................................................................................... 43
Introductie ..................................................................................................................................... 43
Behandeling van AN ...................................................................................................................... 44
Psychofarmacologie ....................................................................................................................... 45
Neuropathofysiologie .................................................................................................................... 46
Obesitas ............................................................................................................................................. 48
Leerdoelen ..................................................................................................................................... 48
Epidemie ........................................................................................................................................ 48
Neurobiologie ................................................................................................................................ 49
Behandeling ................................................................................................................................... 53
Hoorcollege 5: Traumatisch hersenletsel (09-09) .................................................................................. 57
Learning objectives ........................................................................................................................ 57
Reading material............................................................................................................................ 57

, Overview............................................................................................................................................ 57
Definition and classification .......................................................................................................... 57
Epidemiology ................................................................................................................................. 57
Risk factors and causes .................................................................................................................. 57
Long-term implications.................................................................................................................. 58
Classification .................................................................................................................................. 58
Neuropathology............................................................................................................................. 59
Penetrating head injuries (PHI).......................................................................................................... 60
Causes ............................................................................................................................................ 60
Mortality & Severity ...................................................................................................................... 60
Types of injuries ............................................................................................................................. 60
Neuropathology............................................................................................................................. 60
Outcome ........................................................................................................................................ 60
Progression .................................................................................................................................... 61
Closed head injuries (CHI) ................................................................................................................. 61
Definition ....................................................................................................................................... 61
Mild TBI.......................................................................................................................................... 63
Moderate TBI ................................................................................................................................. 64
Severe TBI ...................................................................................................................................... 65
Moderator variables .......................................................................................................................... 66
Age ................................................................................................................................................. 66
Repeated TBIs ................................................................................................................................ 66
Chronic Traumatic Encephalopathy (CTE)...................................................................................... 66
Polytrauma .................................................................................................................................... 66
Alcohol and substance use ............................................................................................................ 66
Summary ........................................................................................................................................... 67
Hoorcollege 6: Genetische ontwikkelingsstoornissen (10-11) .............................................................. 68
Learning outcomes ............................................................................................................................ 68
Learning materials ............................................................................................................................. 68
Overview of genetic mechanisms...................................................................................................... 68
Types of mutations ........................................................................................................................ 68
Neuroconstructivism ..................................................................................................................... 69
Genotype to Phenotype ................................................................................................................ 69
Disorders of known genetic disorders ........................................................................................... 69
Down Syndrome ................................................................................................................................ 69
Genetics ......................................................................................................................................... 70

, Physical characteristics .................................................................................................................. 70
Health concerns ............................................................................................................................. 70
Risk factors..................................................................................................................................... 70
Cognitive phenotype ..................................................................................................................... 71
Language........................................................................................................................................ 71
Gene x Environment ...................................................................................................................... 71
Neural phenotype.......................................................................................................................... 72
Summary Down Syndrome ............................................................................................................ 72
William’s Syndrome ........................................................................................................................... 72
Genetics ......................................................................................................................................... 73
Health concerns ............................................................................................................................. 73
Physical characteristics .................................................................................................................. 73
Visuospatial cognition ................................................................................................................... 73
Language........................................................................................................................................ 73
Hypersociability ............................................................................................................................. 74
Neural phenotype.......................................................................................................................... 74
Environment .................................................................................................................................. 74
Summary Williams Syndrome ....................................................................................................... 75
Fragile-X Syndrome............................................................................................................................ 75
Genetics ......................................................................................................................................... 75
Psychical characteristics ................................................................................................................ 76
Health concerns ............................................................................................................................. 76
Inherited ........................................................................................................................................ 76
Cognitive phenotype ..................................................................................................................... 76
Neural phenotype.......................................................................................................................... 77
Environment .................................................................................................................................. 77
Summary Fragile-X Syndrom ......................................................................................................... 78
Comparison ....................................................................................................................................... 78
Hoorcollege 7: Genderdysforie (12-09) ................................................................................................. 79
Sekse en gender ................................................................................................................................ 79
Leerdoelen ..................................................................................................................................... 79
Sekse versus gender ...................................................................................................................... 79
Sekse en gender in klinische psychologie ...................................................................................... 80
Sekse en gender in onderzoek....................................................................................................... 82
Genderdysforie .................................................................................................................................. 85
Leerdoelen ..................................................................................................................................... 85

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