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26 y.o. w/HA and R-hand clumsiness for weeks. Exam shows difficulty w/rapid alternating movements of hand, overt intention tremor on finger-to-nose, and mildly dysmetric finger tamping. CNS intact and no papilledema. Where will damage show on MRI? - ANSWERCEREBELLUM Mesolimbic DA pathway i...

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Ninja PRITE Part 1 Exam 100%
Correct!!

26 y.o. w/HA and R-hand clumsiness for weeks. Exam

shows difficulty w/rapid alternating movements of

hand, overt intention tremor on finger-to-nose, and

mildly dysmetric finger tamping. CNS intact and no

papilledema. Where will damage show on MRI? - ANSWERCEREBELLUM

Mesolimbic DA pathway includes which structure? - ANSWERVENTRAL STRIATUM

In addiction, dopaminergic neurons project to nucleus

accumbens. Cell bodies of these neurons reside in

which area of brain? - ANSWERVENTRAL TEGMENTAL AREA

Neural plasticity largely mediated through the capacity

to rapidly change in number and morphology which fo

the following? - ANSWERDENDRITIC SPINES

The uncinated fasciculus connects which of the

following brain areas? - ANSWERANTERIOR TEMPORAL AND VENTRAL PRE-FRONTAL

REGIONS

What are cortical columns? - ANSWERFUNCTIONAL UNITS FOR INFORMATION

PROCESSING

Abnormal emotional expressions such as pathological

laughter or crying caused by lesions affecting cortical-

subcortical circuits linking frontal cortex, pons and

what? - ANSWERCEREBELLUM

The most likely reason that adults are superior to

adolescents in abstract thinking. The brain undergoes: - ANSWERSYNAPTIC PRUNING

Dorsal-lateral-pre-frontal cortext plays important role in

what activity? - ANSWERWORKING MEMORY

Drug abuse activates neuro circuits. Generates signals

,in the ventral tegmental area and to where? - ANSWERDOPAMINE INTO THE NUCLEUS ACCUMBENS

Ninety-five percent of right-handed people develop

left hemispheric dominance for language. What

percentage of left handed people develop left

hemispheric dominance for language? - ANSWER75%

Prostaglandin D2 increases extracellular levels of... - ANSWERADENOSINE

Which is a retrograde neurotransmitter? - ANSWERENDOCANNABINOIDS

Characteristics of Ach receptors in cerebral cortex - ANSWERBOTH INHIBITORY AND EXCITATORY

Neurohormone for social bonding - ANSWEROXYTOCIN

28 y.o. hospitalized with paranoid delusions, AH, and

agitation, tx w/Haldol 5, pt becomes rigid & mute, in

days gets choreoform mvmt, has seizures, gets resp

problems leading to ICU admit. Exam shows ovarian

mass, CSF will show antibodies to: - ANSWERNMDA RECEPTORS

Neurotransmitter from responsible for rewarding

nature of drug abuse - ANSWERDOPAMINE

Role of glycine at NMDA receptor - ANSWEROBLIGATE COAGONIST

Low CSF levels of this neurotransmitter metabolites is

associated with suicidality? - ANSWER5-HYDROXYINDOLE ACETIC ACID (5-HIAA)

What is the 5HT3 receptor classification? - ANSWERLIGAND GATED

Pain by neurogenic inflammation mediated by? - ANSWERSUBSTANCE P

Decreased level of what NT is most associated with

depressed mood, poor sleep, and poor impulse

control – ANSWERSEROTONIN

Exposure to light effects which brain structure? - ANSWERSUPRACHIASMATIC NUCLEUS

When does synaptogenesis peak? - ANSWERFIRST 4 YEARS OF LIFE

Where does the neuron morphology in the brain

change the most? - ANSWERPREFRONTAL CORTEX

threatening objects produce startle response prior to

person becoming consciously aware. Connection of

thalamus to what? - ANSWERAMYGDALA

,Huntington's disease characterised by loss of neurons

producing which NT - ANSWERGABA

Adult neurogenesis in which area of the brain? - ANSWERHIPPOCAMPUS

17y/o is evaluated for binge eating associated with a

60 lb weight gain over the past four months. CT shows

a craniopharyngioma that likely disrupts what

structure? - ANSWERVENTROMEDIAL HYPOTHALAMUS

What is an accurate statement about the brain's default

mode network? - ANSWERIS INVOLVED IN REPROCESSING PREVIOUSLY

EXPERIENCED STIMULI



Psych stress increases cortisol and prolonged cortisol is

associated with bad outcomes. Stress also affects other

hormones. Increase in which hormone is correlated

with decreased PTSD severity most likely due to

hormone's anti-glucocorticoid properties: - ANSWERDHEA

Unsteady gait, appendicular ataxia in LE only and

normal eye movement. Walks with lurching broad-

based gait. (8x) - ANSWERCEREBELLAR DEGENERATION (ALCOHOLIC)

Smooth pursuit, saccadic movements impaired. Worse

w vertical gaze. Full ROM w doll head maneuver. Mild

symmetric rigidity/bradykinesia, no tremor. MRI/CSF/

labs unremarkable. Dx? (4x) - ANSWERPROGRESSIVE SUPRANUCLEAR PALSY

26 y/o w HA, clumsiness of right hand x weeks.

Struggles with rapid alternating movements of R

hand, overt intention tremor w finger-to-nose, mildly

dysmetric finger-tapping. CNs nml, no papilledema.

Damage to what is seen on MRI? (3x - ANSWERCEREBELLUM

9 y/o F has 3 month h/o seemingly unprovoked bouts

of laughter. Worse when not sleeping well. Pt does

not feel happy during these episodes. Started

, menstruating 6 months ago, and at Tanner stage 4.

Dx? (2x) - ANSWERHYPOTHALAMIC HAMARTOMA

5 y/o with 4 month history of morning HA, vomiting,

and recent problems with gait, falls, and diplopia: (2x) - ANSWERMEDULLOBLASTOMA

70 y/o develops flaccid paralysis following severe

water intoxication. He develops dysphagia and

dysarthria without other cranial nerve involvement.

Sensory exam is limited but grossly normal, DTR's are

symmetric, and cognition is intact. Likely dx: (X2) - ANSWERCENTRAL PONTINE MYELINOLYSIS

Elderly pt with confusion, lethargy, generalized tonic-

clonic seizure & serum sodium 95 mEq/L may develop

this complication if excessively correcting metabolic

problem. - ANSWERCENTRAL PONTINE MYELINOLYSIS

Young adult gained 70 lbs in last year c/o daily severe

headaches sometimes associated with graying out of

vision. Papilledema present. CT and MRI brain no

abnormalities but ventricles smaller than usual. Goal

of treatment in this case: (2x) - ANSWERPREVENT BLINDNESS

Superior homonymous quadrantic defects in the visual

fields result from lesions to which of the following

structures? (2x) - ANSWERTEMPORAL OPTIC RADIATIONS

Severe occipital HA, BL papilledema and no other

Visual problem in pituitary tumor compressing optic

chiasm (10x) - ANSWERBITEMPORAL HEMIANOPSIA

60 y/o right-handed M, getting lost, only writes on

right half of paper. Left-sided hemi-neglect. Where is

the lesion? (8x) - ANSWERRIGHT PARIETAL LOBE

Which cancer has the highest likelihood of going to

brain? - ANSWERLUNG

66 y/o c/o frequent falls, several-month hx of anxiety,

unwillingness to leave home. On exam, mild

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