100% tevredenheidsgarantie Direct beschikbaar na betaling Zowel online als in PDF Je zit nergens aan vast
logo-home
CMMB 403 Final Exam Questions and Answers 100% Solved €13,23   In winkelwagen

Tentamen (uitwerkingen)

CMMB 403 Final Exam Questions and Answers 100% Solved

 0 keer bekeken  0 keer verkocht
  • Vak
  • CMMB 403
  • Instelling
  • CMMB 403

CMMB 403 Final Exam Questions and Answers 100% Solved What are the origins of the optic vesicle and the lens? - optic vesicle = forebrain (neural ectoderm) lens = surface epidermis --> placode Describe the process of lens induction - 1. the optic vesicle (forebrain) induces thickening of t...

[Meer zien]

Voorbeeld 4 van de 70  pagina's

  • 20 oktober 2024
  • 70
  • 2024/2025
  • Tentamen (uitwerkingen)
  • Vragen en antwoorden
  • CMMB 403
  • CMMB 403
avatar-seller
©JOSHCLAY 2024/2025. YEAR PUBLISHED 2024.

CMMB 403 Final Exam Questions and

Answers 100% Solved


What are the origins of the optic vesicle and the lens? - ✔✔optic vesicle =

forebrain (neural ectoderm)

lens = surface epidermis --> placode

Describe the process of lens induction - ✔✔1. the optic vesicle (forebrain)

induces thickening of the surface epidermis (prospective lens placode)

2. the optic vesicle pinches in to form the optic cup and the lens invaginate

as well (lens placode comes into contact w/ the optic vesicle)

3. the optic cup forms two layers: neural retina and the pigmented retina

4. the lens pinches off

What is a placode? - ✔✔epithelial thickening of ectoderm that develops into

neurons or other parts of the sensory organs

What is the function of jervine? - ✔✔Its a SHH inhibitor, preventing the

repression of Pax6 at the midline, causing cyclopia

What is the function of Pax6? - ✔✔Eye development

,©JOSHCLAY 2024/2025. YEAR PUBLISHED 2024.

Where is Shh expressed along the midline? - ✔✔- the prechordal plate

(floor plate of the neural tube) and the notochord

How does the signalling in Mexican cave-dwelling fish differ for eye

development? - ✔✔- they sent need to see because they live in caves

- so they have evolved to over express Shh and down regulated Pax6

everywhere = no eye development

What is the function of the Rx gene? - ✔✔retinal development --> functions

to maintain the expression of Pax6 (AMPLIFY PAX6)

Where do neural crest cells form? - ✔✔The entire length of the neural tube

How do neural crest cells migrate? When in development does migration

occur? - ✔✔They undergo an EMT

- migrate in the 4th week of development

What transcription factors are necessary to cause the release of E-cadherin

and allow the neural crest cells to undergo an EMT and migrate -

✔✔Snail/Slug --> neural crest cells lose E-cadherin and become

mesenchymal and can migrate through the body

,©JOSHCLAY 2024/2025. YEAR PUBLISHED 2024.

What are the four main regions of neural crest and what do they form? -

✔✔1. Vagal/ Sacral: forms the parasympathetic neurons that innervate the

gut

2. trunk: forms the sensory neurons and dorsal root ganglia (and the

melanocytes)

3. cranial: forms the bones and cartilage of the face

4. cardiac: forms the outflow tracts of the heart

What chemotaxis elements are responsible for the migration of the

vagal/sacral neural crest cells into the gut? - ✔✔gut produces GDNF signal

which binds to the RET receptors on the neural crest cells -->

chemoattraction that drives the movement of neural crest cells into the gut

What causes Hirschprungs disease? - ✔✔mutation in GDNF or the RET

receptor to prevent chemoattraction driving the movement of neural crest

cells to the gut

- dont get proper peristalsis in the gut anymore

What are the two pathways that trunk neural crest cells can migrate down?

Which one forms what and which happens first? - ✔✔First - the ventral

, ©JOSHCLAY 2024/2025. YEAR PUBLISHED 2024.

pathway: neural crest cells migrate to the anterior sclerotome where they

either become the sympathetic ganglia or the dorsal root ganglia



Second - the more dorsolateral pathway: future melanocytes migrate

between the dermis and epidermis

Where are the cell bodies of the sensory neurons found? - ✔✔- found in

the dorsal root ganglia, not right in the central nervous system

What drives the migration of trunk neural crest through the anterior

sclerotome instead of the posterior? - ✔✔- the neural crest cells express

Eph receptors

- the posterior sclerotome expresses ephrins

- these repel eachother

What do the neural crest cells who stay in the anterior sclerotome become?

- ✔✔if they stay in the anterior sclerotome --> become more dorsal cell

types DRG

What do the neural crest cells who are repulsed and migrate out of the

anterior sclerotome become? - ✔✔cells that migrate out of the anterior

Voordelen van het kopen van samenvattingen bij Stuvia op een rij:

Verzekerd van kwaliteit door reviews

Verzekerd van kwaliteit door reviews

Stuvia-klanten hebben meer dan 700.000 samenvattingen beoordeeld. Zo weet je zeker dat je de beste documenten koopt!

Snel en makkelijk kopen

Snel en makkelijk kopen

Je betaalt supersnel en eenmalig met iDeal, creditcard of Stuvia-tegoed voor de samenvatting. Zonder lidmaatschap.

Focus op de essentie

Focus op de essentie

Samenvattingen worden geschreven voor en door anderen. Daarom zijn de samenvattingen altijd betrouwbaar en actueel. Zo kom je snel tot de kern!

Veelgestelde vragen

Wat krijg ik als ik dit document koop?

Je krijgt een PDF, die direct beschikbaar is na je aankoop. Het gekochte document is altijd, overal en oneindig toegankelijk via je profiel.

Tevredenheidsgarantie: hoe werkt dat?

Onze tevredenheidsgarantie zorgt ervoor dat je altijd een studiedocument vindt dat goed bij je past. Je vult een formulier in en onze klantenservice regelt de rest.

Van wie koop ik deze samenvatting?

Stuvia is een marktplaats, je koop dit document dus niet van ons, maar van verkoper JOSHCLAY. Stuvia faciliteert de betaling aan de verkoper.

Zit ik meteen vast aan een abonnement?

Nee, je koopt alleen deze samenvatting voor €13,23. Je zit daarna nergens aan vast.

Is Stuvia te vertrouwen?

4,6 sterren op Google & Trustpilot (+1000 reviews)

Afgelopen 30 dagen zijn er 62890 samenvattingen verkocht

Opgericht in 2010, al 14 jaar dé plek om samenvattingen te kopen

Start met verkopen
€13,23
  • (0)
  Kopen