BME 520:195 Module 3 Quiz Questions With Answers |45 Pages
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BME 520
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BME 520
Where is Foxf1 expressed in mesoderm - ️️Lateral mesoderm
Where is Hensen's node located? - ️️Anterior portion of primitive streak
Wht is the different between anterior and posterior endoderm in its role in inducing cardiogenic mesoderm? What effect does this have on the posterior lateral...
BME 520: Module 3 Quiz
Where is Foxf1 expressed in mesoderm - ✔ ✔
Lateral mesoderm
Where is Hensen's node located? - ✔ ✔ Anterior
portion of primitive streak
Wht is the different between anterior and posterior
endoderm in its role in inducing cardiogenic mesoderm?
What effect does this have on the posterior lateral plate
mesoderm? - ✔ ✔ Posterior endoderm does not
inhibit Wnt signaling. Due to presence of Wnt signaling,
posterior lateral plate mesoderm gives rise to
angiogenesis.
Why does first heart field only give rise to first ventricle? -
✔ ✔ Progenitors have limited proliferative capacity
and give rise to only the left ventricle
Wnt signaling role in respiratory tube development - ✔
✔ Wnt signals from mesenchyme pattern lung and
tracheal primordium of gut tube.
,e.g. Wnt signaling induces ciliated respiratory epithelia in
trachea while sFRPs blocking Wnt induce squamous
esophageal epithelia
________ endoderm forms the pharynx and its four
pouces in close proximity with the ectoderm - ✔ ✔
Anterior
Angiogenesis begins (before/after) vasculogenesis - ✔
✔ before
Angiopoietins - ✔ ✔ binding to endothelial Tie2
receptors mediates interactions of vessels with pericytes
Arteries vs veins - ✔ ✔ Arteries; extensive coating of
smooth muscle and elastic matrix for high pressure flow
veins: less msucular and have valves to direct flow
specification caused by difference in precursors exposure
to notch signaling
,As the primitive streak regresses it leaves behind what? -
✔ ✔ The underlying rod of notochord tissue, which
will eventually span most of embryonic rostrocaudal axis
As the primitive streak regressive what lengthens? - ✔
✔ The notochord
Blood islands - ✔ ✔ Hemangioblasts condensed. The
outer cells become angioblasts that differentiate into
endothelial cells of blood vesicles. The inner cells are not
primitive blood cells.
Blood Vessel Formation: What TF is critical for formation
of blood cells? - ✔ ✔ Runx1
Cardiac Derivation from hPSCs (Steps) - ✔ ✔ -TGF
and BMP signaling present during hPSC culture and
differentiation
-Early treatment with CH, a Wnt agonist, induces
mesoderm
, -Day 3: blockage of Wnt signaling with IWP induces
cardiac differentiation
-Dardiomyocytes express cytoskeletal proteins Troponin I
& T, myosin heavy chain (MHC), and a-actinin
Cardiac differentiation: BMP signaling in absence of Wnt
induces expression of what TFs that are critical for cardiac
diff - ✔ ✔ Nkx2.5 and Mesp1
Where are neurons generated? - ✔ ✔ In the CNS
and in multiple distant regions by neural crest cells or in
sensory organs
Where do lateral motor neurons of the spinal cord project?
- ✔ ✔ To limb muscles
Where do satellite cells sit in adults? - ✔ ✔ The basal
lamina surrounding the myotube
Where does all skeletal musculature in a vertebrate body
come from? - ✔ ✔ The dermamyotome except for
head muscles
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