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ACBS 419 questions and correct answers rated A+
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ACBS 419 questions and correct answers rated A+
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ACBS 419 questions and correctanswers rated A+
what complement peptide is cleaved by CD46? - correct answer ✔✔C3b (and C4b)
What is Not an activity of complement? - correct answer ✔✔Activation of T cells
What cell is the bridge between innate and adaptive immune system? - correct answer ✔✔dendritic cell
what cell secrete mucus, a part of the innate immunity? - correct answer ✔✔goblet cells
what is the C3-C5 convertase? - correct answer ✔✔C4b2a3b
chemokine give the immune system information about what? - correct answer ✔✔where a pathogen is
IRAK4 deficiency is seen in one of the case studies, what signaling pathway is disrupted by this
deficiency? - correct answer ✔✔MyD88 signaling
this cell is involved in bactericidal mechanisms and antigen presentation in the periphery? - correct
answer ✔✔macrophages
what region of the antibody contains the antigen binding site? - correct answer ✔✔variable light chain
during negative selection of B cells in the bone marrow, what will happen if the B cell binds self-antigen?
- correct answer ✔✔it dies via apoptosis
what is NOT a function of antibodies? - correct answer ✔✔disposal of red blood cells (the spleen does
this)
,where fo T cells originate? - correct answer ✔✔bone marrow but develop in thymus
what cell does NOT express MHC class 2 on its surface? - correct answer ✔✔neutrophil
what cells do NOT posses MHC class 1 on their surface? - correct answer ✔✔they all do (basically all cells
produce MHC class 1 and B cells have both)
CD4 helper T cells bind to which MHC class? - correct answer ✔✔MHC class 2
what do CD8 cytotoxic T cells do? - correct answer ✔✔kill
what is lysozyme an example of? - correct answer ✔✔antimicrobial peptide
what is the function of the proteasome? - correct answer ✔✔degrades proteins
what recognizes PAMPs? - correct answer ✔✔Toll-like receptors (TLRs)
where does negative selection occur for T cells? - correct answer ✔✔thymus (undergo positive and
negative selection in thymus)
what do lysosomes do? - correct answer ✔✔kill gram positive bacteria by cleaning NAM-NAG bond
(cannot kill gram negative bacteria)
what does B1 defensin do? - correct answer ✔✔makes a pore in the bacteria membrane causing lysis
what is RegIII-alphas activity and what type of bacteria are resistant to it? - correct answer ✔✔forms a
pore in the membrane, gram negative bacteria
what do panted cells secrete and to where? - correct answer ✔✔AMP's; mucus
, what are transcriptional levels regulated by in terms of the innate immune response? - correct answer
✔✔PAMP concentration
how does the classical pathway begin? - correct answer ✔✔C1q binds to the bound IgM molecule
what molecule binds to the antigens directly on bacterial surfaces? - correct answer ✔✔B cells (light and
heavy chains bind)
what cleaves C3 into C3a and C3b? - correct answer ✔✔C4b2a
what is C4b's function? - correct answer ✔✔covalently bind pathogen and aids in phagocytosis (helps in
opsonization)
what are the three anaphyltoxins? - correct answer ✔✔C3a, C5a, and C2b
what is C8's function? - correct answer ✔✔binds C5b67 and initiates C9 polymerization
cytokine binding ____ leads to phosphorylation of ____ - correct answer ✔✔Jack cytokine receptor;
STAT (in the MyD88 cascade)
what is phosp-STATs function? - correct answer ✔✔migrates to nucleus and alters transcription of genes
(in MyD88 pathway)
what binds adhesion molecules on vascular endothelium near sites of infection, thus receiving cytokine
signaling? - correct answer ✔✔monocytes
what local effect of IL-1-beta? - correct answer ✔✔activates endothelium and lymphocytes, local tissue
destruction
what is the systemic effect of TNF-alpha? - correct answer ✔✔fever, shock, inflammation
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