Lynch syndrome Samenvattingen, Aantekeningen en Examens

HBOC correct answers breast, ovarian, prostate, melanoma Familial Adenomatous Polyposis correct answers CHRPE (congenital hypertrophy of the retinal pigment epithelium) Li-Fraumini correct answers early breast, sarcoma, brain, leukemia, adrenocortical, choroid plexus tumors (childhood), fam hx childhood onset tumors Cowden correct answers Folliular Thyroid, Breast, uterine, macrocephaly, Lhermitte-Duclose disease (LDD)= cerebellar dysplastic gangliocytoma Cowden correct answers Papil...

An Ames test of a compound suspected to be a mutagen was examined before and after incubation with rat liver extract. Based on the results shown, what do you conclude? correct answers Compound is mutagenic without liver enzymes and this activity is further enhanced by liver enzymes Lynch syndrome is a human genetic disease characterized by ~100-fold higher incidence of colon cancer in men and women - and uterine cancer in women - by the age 50, as compared to the general population. Which sta...

AANP - Walden (Women's Health & Pregnancy)/ AANP - Walden (Women's Health & Pregnancy), Walden University. Questions and Correct Answers. Updated 2024. For post menopausal bleeding: DO ULTRASOUND FIRST OR REFER FOR ENDOMETREAL BIOPSY Dominant breast/breast cancer: characteristics and diagnostics mass one side feels hard, irregular, immobile, located tail of spence, skin color peu d orange (resembles orange peel), dimpling retraction, painless, bloody nipple discharge DX: order mammogr...

USMLE STEP 1- First AidDiseases/Disorders/Deficiencies/Syndromes Exam 2023 (A+) Adenosine deaminase (ADA) deficiency - ANS-An immunodeficiency disorder and one type of SCIDs that is caused by an *inborn error in the metabolism of adenine*. The accumulation of adenine destroys both B and T lymphocytes. Increase in dATP is lymphotoxic Lesch-Nyhan syndrome - ANS-*Defective purine salvage due to absent HGPRT*, which converts hypoxanthine to IMP and guanine to GMP. Results in *excess uric ...

A 45yearold man with colon cancer comes for genetic counseling. In conjunction with microsatellite instability testing, which of the following tests done on his colon tumor would be MOST helpful in deciding about testing for germline Lynch syndrome mutations? A. comparative genomic hybridization B. tumor cell karyotype C. immunohistochemical staining D. loss of heterozygosity correct answers C. immunohistochemical staining A 43yearold woman seeks genetic counseling because of a recent di...

NR507 Midterm Test Questions with Complete Solutions What is epigenetics? - ANSWER The study of heritable changes in gene expression or phenotype casued by mechanisms *other* than changes in DNA sequences. DNA methylation - ANSWER The attachment of a methyl group to a cytosine base is followed by a guanine base...causes a gene to become transcriptionally inactive or silent. Epigenetic processes play a major role in cancer initiation, progression, and treatmen...

MB (ASCP) 2023 Questions and Answers 100% correct Consider the table below where a child and a possible father (PF) share the listed paternity indices for each locus listed (LOC-A1, LOC-B2, LOC-C3, LOC-D4). Locus Tested PF Child Paternity Index LOC-A1 3 2/3 2.18 LOC-B2 7/5 5 0.798 LOC-C3 15/17 9/17 5.21 LOC-D4 12 12 1.37 Based on the data presented in the table, what is the combined paternity index, CPI, from the loci tested: LOC-A1, LOC-B2, LOC-C3 and LOC-D4? 12.42 9.558 15.56 2....

Genetic Counseling Boards Review Questions and Answers (summer 2023/24). - A young patient (5yrs) presents for the first time to a new dentist with crowded teeth, making them very hard to clean. In further exploration of the issue, she learns that the child had delayed eruption of his teeth. The patient's mother also relays that her pediatrician has several times noted how prominent the veins of his scalp are and his short stature. However, she thinks that this is just part of the spectrum ...

Consider the table below where a child and a possible father (PF) share the listed paternity indices for each locus listed (LOC-A1, LOC-B2, LOC-C3, LOC-D4). Locus Tested PF Child Paternity Index LOC-A1 3 2/3 2.18 LOC-B2 7/5 5 0.798 LOC-C3 15/17 9/17 5.21 LOC-D4 12 12 1.37 Based on the data presented in the table, what is the combined paternity index, CPI, from the loci tested: LOC-A1, LOC-B2, LOC-C3 and LOC-D4? 12.42 9.558 15.56 2.38 - ANSWER 12.42 ( CPI is calculated by multiplying ...

NR507 Midterm Test Questions with Complete Solutions What is epigenetics? - ANSWER The study of heritable changes in gene expression or phenotype casued by mechanisms *other* than changes in DNA sequences. DNA methylation - ANSWER The attachment of a methyl group to a cytosine base is followed by a guanine base...causes a gene to become transcriptionally inactive or silent. Epigenetic processes play a major role in cancer initiation, progression, and treatment. Evidence: 20% of people ...