Lynch syndrome Samenvattingen, Aantekeningen en Examens

ASCP (MB) Exam BCR-ABL Genes involved in cancer caused by t(9;22) CML Cancer caused by t(9:22) EWS-FLI1 Genes involved in cancer caused by t(11;22) Ewing sarcoma Cancer caused by translocations involving 22q12 HER2(ERBB2) - 17q21.1 Receptor tyrosine kinase commonly overexpressed in breast cancer IHC, rtPCR, FISH Methods used to assess overexpression of common oncogenes KRAS Most common oncogene in human cancer, which activates MAPK pathway t(11,2...

A patient has endured several dosage adjustments of his tricyclic antidepressant, so the provider recommends genetic testing. Which statement correctly describes the rationale for genetic testing? a. The CYP2D6 gene influences metabolism of tricyclic antidepressants and certain other drugs. b. The HER2 gene is a tumor marker that impacts metabolism of tricyclic antidepressants. c. The BRCA2 gene influences metabolism of certain drugs and increases the risk for breast cancer. d. The x linke...

USLME – Biochemistry Exam Questions With Accurate Answers. Amino acids necessary for purine synthesis - answerGlycine Aspartate Glutamine Leflunomide MOA - answerinhibits dihydroorotate dehydrogenase 5-fluorouracil and capecitabine (its prodrug) MOA - answerForm 5-F-dUMP which inhibits thymidylate synthase (therefore decreasing dTMP) Adenosine deaminase deficiency (Pathogenesis, presentation) - answerADA needed for degradation of adenosine Deficiency causes: excess ATP and dATP --&gt...

Hereditary Breast and Ovarian Cancer correct answers BRCA 1/2 Breast 50-87% Second primary tumor 50-64% BRCA 1: 20-45% BRCA 2: 10-30% BRCA 2: Male breast 6-10% Li-Fraumeni Syndrome correct answers -Sarcoma, breast, leukemia, adrenal and many others -May present in almost every way (ie all family members with same cancers or all with different) -Adrenocortical carcinoma considered pathognomonic -50% have some type by 30, 90% by age 60 -TP53 accounts for 70% of individuals Beckwit...

AANP - Walden (Women's Health & Pregnancy)/ AANP - Walden (Women's Health & Pregnancy), Walden University. Questions and Correct Answers. Updated 2024. For post menopausal bleeding: DO ULTRASOUND FIRST OR REFER FOR ENDOMETREAL BIOPSY Dominant breast/breast cancer: characteristics and diagnostics mass one side feels hard, irregular, immobile, located tail of spence, skin color peu d orange (resembles orange peel), dimpling retraction, painless, bloody nipple discharge DX: order mammogr...

Small bowel carcinoma (General Surgery EOR - Smarty PANCE) Exam Questions and Answers 100% Pass What is small bowel carcinoma? Small bowel carcinoma is a rare malignant tumor originating in the small intestine, comprising only a small percentage of all gastrointestinal malignancies. What are common symptoms of small bowel carcinoma? Symptoms can include abdominal pain, weight loss, nausea, vomiting, anemia, and gastrointestinal bleeding. What are the risk factors associated with small b...

NSG 533 Oncogenesis Exam Questions and Answers Inherited forms of cancer are __________ mutations are thought to account for approximately _______% of all adult cancers - ANSWER germ line 5-10% Hereditary diffuse gastric cancer (HDGC) susceptibility syndrome involves germ line mutations in which gene? What does it encode? - ANSWER CDH1 gene that encodes the protein E-cadherin Hereditary breast & ovarian cancer is more common in which ethnic group? - ANSWER ...

Generic Boards Review summary study guide rated 5 stars (rcommended to getting straight As) Osteogenesis imperfecta - Genes: COL1A1 (ch17; more severe pheno w/mutn b/c there are 2 alpha strands vs. 1 beta strand), COL1A2 (ch7), form protein triple helix Type I -- AD, mild, blue sclera, brittle bones, no deformity collagen: normal quality, AMOUNT is reduced Type II: AD, neonatal lethal, abnormal collagen Type III: AD, progressive deforming, fractures at birth, small, blue sclera Type ...

Small bowel carcinoma (General Surgery EOR - Smarty PANCE) Exam Questions and Answers 100% Pass What is small bowel carcinoma? Small bowel carcinoma is a rare malignant tumor originating in the small intestine, comprising only a small percentage of all gastrointestinal malignancies. What are common symptoms of small bowel carcinoma? Symptoms can include abdominal pain, weight loss, nausea, vomiting, anemia, and gastrointestinal bleeding. What are the risk factors associated with small b...

D027 Practice Test Questions and Answers 2023 A patient has endured several dosage adjustments of his tricyclic antidepressant, so the provider recommends genetic testing. Which statement correctly describes the rationale for genetic testing? a. The CYP2D6 gene influences metabolism of tricyclic antidepressants and certain other drugs. b. The HER2 gene is a tumor marker that impacts metabolism of tricyclic antidepressants. c. The BRCA2 gene influences metabolism of certain drugs and increa...