Rtk pathway - Samenvattingen, Aantekeningen en Examens

CMMB 403 Midterm 1 Question and answers 100% correct CMMB 403 Midterm 1 Describe the RTK signal transduction pathway when activated by the FGF ligand FGF ligand dimerizes RTK receptor. Receptor is phorphorylated and attracts adaptor/GEF. GEF begins phosphorylation cascade: GEF to Ras to Raf to Mek to Erk to TF. TF transcribes gene Describe the JAK-STAT pathway when activated by FGF FGF ligand dimerizes RTK. JAK2 proteins cross-phosphorylate. Both JAK2s phosphorylate a STAT5 (which is...

CMMB 403 Midterm 1 Question and answers already passed 2024Describe the RTK signal transduction pathway when activated by the FGF ligand FGF ligand dimerizes RTK receptor. Receptor is phorphorylated and attracts adaptor/GEF. GEF begins phosphorylation cascade: GEF to Ras to Raf to Mek to Erk to TF. TF transcribes gene Describe the JAK-STAT pathway when activated by FGF FGF ligand dimerizes RTK. JAK2 proteins cross-phosphorylate. Both JAK2s phosphorylate a STAT5 (which is a cytoplasmic tyr...

cmmb midterm Question and answers verified to passcmmb midterm RTK pathway and FGFs - correct answer Ligand, RTK, GEF, RAS, RAF, MEK,ERK, TF, Transcription morula, blastula, gastrula blastomere - correct answer morula: cleavage stage embryo, no cavityblastula: cleavage stage, when there is a cavity in the embryogastrula: embryo undergoing gastrulationneurula: embryo as neural tube is formingblastomere: any cell of a cleavage stage embryo cleavage - correct answer rapid cell divisio...

CMMB 403 Midterm 1Describe the RTK signal transduction pathway when activated by the FGF ligand FGF ligand dimerizes RTK receptor. Receptor is phorphorylated and attracts adaptor/GEF. GEF begins phosphorylation cascade: GEF to Ras to Raf to Mek to Erk to TF. TF transcribes gene Describe the JAK-STAT pathway when activated by FGF FGF ligand dimerizes RTK. JAK2 proteins cross-phosphorylate. Both JAK2s phosphorylate a STAT5 (which is a cytoplasmic tyrosine kinase). The STAT5s dimerize and tr...

cmmb midterm Question and answers already passed 2024 RTK pathway and FGFs - correct answer Ligand, RTK, GEF, RAS, RAF, MEK,ERK, TF, Transcription morula, blastula, gastrula blastomere - correct answer morula: cleavage stage embryo, no cavityblastula: cleavage stage, when there is a cavity in the embryogastrula: embryo undergoing gastrulationneurula: embryo as neural tube is formingblastomere: any cell of a cleavage stage embryo cleavage - correct answer rapid cell divisions divide th...

RTK in NGF One ligand binds 2 receptors causing dimerization + phosphorylation at tyrosine residues. Monomers phosphorylate each other + can activate effectors downstream. RTK in Insulin Receptors 2 ligands each bind receptors on the alpha side, causing conformational change to each alpha-beta pair. The beta subunits phosphorylate each other and can activate effectors downstream. Female Sexual Differentiation 1. Ovaries develop from cortex while medulla regresses 2. Wolffian du...

Signal transduction pathway - Organization and function of cell signaling process Ligand-receptor binding - Experiment to measure interaction between ligand and receptor GPCR signaling - Signal transduction through G-protein coupled receptors RTK signaling - Signal transduction through receptor tyrosine kinases Signal transduction experiments - Interpretation of data from experiments on cell signaling Kd (Dissociation constant) - Quantitative measure of receptor-ligand affinity

CPPS EXAM PRACTICE QUESTIONS WITH CORRECT ANSWERS 2023/2024 (Graded). What isSH1 domain characterized by? - Correct Answer-Catalytic domain of a protein, for example the receptor. and it has the kinase activity. It is responsible for phosphorylating tyrosine residues. What is SH2 domain characterized by? - Correct Answer-Binds peptides with consensus (positional information on C-terminal side of the phosphorylated tyrosine). Very specific. Mediates protein-protein interactions in cellular ...

CPPS 325 FINAL EXAM QUESTIONS WITH CORRECT ANSWERS 2023/2024 Graded A+. What is the only example of conformational change activation? - Correct Answer-Insulin receptor kinase. All other RTKs are activated through forms of dimerization. What are the two forms of dimerization? - Correct Answer-i) Receptors exist as unactivated dimers until ligand binds (Twist theory) ii) exist as monomers that are brought together and activated by ligand binding. What is the most common method of dimerizatio...

CPPS 325 FINAL EXAM WITH 100% CORRECT ANSWERS 2023/2024 Graded A+. What are the 5 well-known enzyme-linked cell surface receptors? - Correct Answer-1. Receptor Guanylyl Cyclase: produces cGMP 2. RTK: phosphorylate tyrosine residues leading to association of signalling molecules and cascade 3. TK Associated Receptors: associate with proteins having TK activity 4. Receptor Tyrosine Phosphates: Removes phosphate on tyrosine residues 5. Receptor Serine/Threonine Kinases: phosphorylate specific...