Serine proteases - Samenvattingen, Aantekeningen en Examens

Describe the different parts of a typical antibody molecule? Ans: Y-structure Heavy chain is lower portion and upper portion of Y, macrophage binding domain Light chain is upper arms of Y, hypervariable antigen binding domain 2 heavy chains, 2 light chains One constant macrophage binding domain one hypervariable antigen binding region What is meant by opsonization? Ans: When a pathogen is tagged by antibodies, complement or other molecules to facilitate consumption by a macrophage or n...

BRS: BIOCHEM NITROGEN METABOLISM ?S EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS 1. The answer is A. Trypsin cleaves and thus activates the pancreatic zymogens, converting chymotrypsinogen to the active form, chymotrypsin, and the procarboxypeptidases to the active carboxypeptidases. If trypsin were inactive, the other proteases could not be activated because enteropeptidase is specific for trypsinogen. Pepsin is found in the stomach, whereas aminopeptidases are intestinal enzymes found o...

A complex organic molecule that is necessary for enzyme function but is NOT permanently associated with the enzyme is a: A) prosthetic group. B) cofactor. C) holofactor. D) coenzyme. E) metal ion. - D) coenzyme. A double-reciprocal plot of 1/V0 versus 1/[S] for an enzyme in the presence of increasing concentrations of an uncompetitive inhibitor will have lines corresponding to the different inhibitor concentrations that are BEST described by which statement? A) The lines will intersect...

A nonapeptide was determined to have the following amino acid com position: (Lys)2, (Gly) 2, (Phe) 2, His, Leu, Met. The native peptide was incubated with 1-fluoro-2,4- dinitrobenzene (FDNB) and then hydrolyzed; 2,4-dinitrophenylhistidine was identified by HPLC. When the native peptide was exposed to cyanogen bromide(CNBr), an octapeptide and free glycine were recovered. Incubation of the native peptide with trypsin gave a pentapeptide, a tripeptide, and free Lys. 2,4-Dinitrophenyl-histidin...

Med Chem II Exam #1 With 100% Correct Answers 2024 What side of the growing peptide chain does coupling with DIC add to in solution? N-terminus Protecting group used with an acid reagent Boc Protecting group used with a base reagent Fmoc Protecting group used with Pd/C, H2 reagent Cbz Advantages of solid phase peptide synthesis (3) 1. Can drive reactions to completion by using huge excesses of reagents 2. Easy purification after each chemical step 3. Widely diverse selection of res...

BB 450 Exam 2 Questions And Answers Chymotrypsin: - ANS-has an S1 pocket that determines specificity of protease action Attack by the alkoxide ion on the carbonyl carbon of the substrate of a serine protease causes - ANSWith respect to serine proteases, - ANS-a reaction intermediate is stabilized in the oxyanion hole The S1 pocket of serine proteases - ANS--is where the proper substrate binds -is near the catalytic triad determines which amino acid side chain is bound With respect to as...

Biochemistry NBME Exam 2024 Well Revised and Verified Answers Updated Proteoglycans Act as molecular sieves in ECM, CT, and cartilage GAGs are the long polysacc chains attached to core protein GAG is heavily hydrated and cushions (has "-" charge) Degraded via lysosomal pathway (defect = MPS) Glycolipids A.K.A. sphingolipids Made with ceramide lipid base Serine + palmitoyl-CoA => sphingosine (+FFA) => ceramide Carb part sticks out into ECM (same w/ glycoproteins) Side chain p...

Common examples of chromosomal translocated genes associated with lymphomas MYC: stimulates entry into the cell cycle BCL2: suppresses apoptosis BCL6: suppresses the transcription of other genes necessary for cell growth Population in which acute lymphoid leukemia (ALL) with a stem cell phenotype is most common Pediatric population Previous Play Next Rewind 10 seconds Move forward 10 seconds Unmute 0:00 / 0:15 Full screen Brainpower Read More Primary laboratory te...

BB 450 Exam 2 Questions And Answers Chymotrypsin: - ANS-has an S1 pocket that determines specificity of protease action Attack by the alkoxide ion on the carbonyl carbon of the substrate of a serine protease causes - ANSWith respect to serine proteases, - ANS-a reaction intermediate is stabilized in the oxyanion hole The S1 pocket of serine proteases - ANS--is where the proper substrate binds -is near the catalytic triad determines which amino acid side chain is bound With respect to as...

ADP is secreted from the: dense granules beta granules delta granules alpha granules correct answers dense granules Factor III is known as prothrombin time calcium christmas factor tissue factor correct answers tissue factor Which of the following is true regarding the plasma coagulation zymogens? - are haptens that induce peptide binding to make larger active molecules - activation normally occurs throughout the tissues of the body when vascular injury occurs - serine proteas...