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Summary UNDERSTANDING ACTIVATION ENERGY R50,00
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  3. Vaal University Of Technology (VUT)
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  5. Biochemistry

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Summary UNDERSTANDING ACTIVATION ENERGY
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Unstanding Metabolons, enzyme–enzyme assemblies that mediate substrate channeling, This summary also explains why ATP is considered as a high energy molecule, it also describes exergonic and endergonic. understanding of energy coupling and activation energy.

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  • June 1, 2021
  • 4
  • 2021/2022
  • Summary

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Metabolons are transient multi-protein complexes of sequential
enzymes that mediate substrate channeling. They differ from multi-
enzyme complexes in that they are dynamic, rather than permanent,
and as such have considerably lower dissociation constants. Despite the
fact that a huge number of metabolons have been suggested to exist in
plants, most of these claims are erroneous as only a handful of these
have been proven to channel metabolites.

The formation of metabolons allows the intermediate product from
one enzyme to be passed (channelling) directly into the activesite of
consecutive enzymes of the metabolic part way. During the functioning
of metabolons, the amount of water needed to hydrate the enzymes is
reduced and enzyme activity is increased[citation needed].

Enzymes may be loosely held together by a weak non convalent bonds
example glycolysis.

Metabolons may increase flux by increasing the local concentration
of intermediates, decreasing the concentration of enzymes needed to
maintain a given flux, directing the products of a pathway to a specific
subcellular location or minimizing the escape of reactive intermediates.

Le Chatelier's principle (also known as "Chatelier's principle" or "The
Equilibrium Law") states that when a system experiences a disturbance
(such as concentration, temperature, or pressure changes), it will
respond to restore a new equilibrium state.

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