Samenvatting
Summary Research Q8 - Personalized Healthcare
Summary Research Q8 - Personalized Healthcare, including lectures and self study assignments
[Meer zien]Voorbeeld 2 van de 7 pagina's
Voorbeeld 2 van de 7 pagina's
In winkelwagengesponsord bericht van onze partner
1 beoordeling
Door: marasnaa • 3 jaar geleden
Voorbeeld van de inhoud
Renske de Veer (rdeveer)Summary Personalized healthcare: overview.
HC 1: Introduction to Personalized Healthcare Research
Personalized healthcare: match diagnostics and therapies to the specific characteristics and needs of
a patient.
Personalized medicine: is an emerging practice of medicine that uses an individual’s genetic profile to
guide decisions made in regard to the prevention, diagnosis, and treatment of disease.
- The ability to offer the right drug, to the right patient, for the right disease, at the right time,
with the right dosage, enhanced by new biological knowledge.
- Genomic/genetic testing & proteomic profiling
Traditional medicine is based on: Family history, socio-economic circumstance & environmental
factors.
New paradigm:
- Results in more efficient medical care, because the correct drug is chosen earlier in the
treatment of the disease
- Future paradigm: aim to prevent disease.
, Renske de Veer (rdeveer)
HC 2: Molecular innovations and future directions
- Great advances in technology: not about how you will do it but what you will do (?)
o Exponential technology development
Consider individual differences in life science research → people are different and we can
molecularly phenotype them.
Personalized medicine: translation to personalized healthcare is the problem.
- Health care medicine
- Precision medicine/targeted medicine
The right drug for right patient at right dose at right time = precision medicine or targeted medicine.
More broadly ‘personalized healthcare’, may be thought of as the tailoring of medical treatment to
the individual characteristics, needs, and preferences of a patients during all stages of care, including
prevention, diagnosis, treatment and follow-up.
Now drug not toxic and beneficial
B-RAFv600E cells always grow and become cancer cells. Raf inhibitors will block pathways, block cell
growth and inhibit cancers that have a B-RAFv600E mutation. 60% of melanoma patients have B-
RAFv600E mutation (gets via 2 phosphorlation). If you can screen the tumour for the mutation, then
you will have the basis for personalized healthcare!
Zelboraf is a B-RAF inhibitor.
Oncogenic addiction: whole cell focusses on one production (growth/proliferation)
(Kinase inhibitor: very insoluble → couldn’t make it soluble. Needs to be soluble to work.)
➔ Personalized medicine is risky (need lots of experts → cannot know everything on your own),
but profitable business.
- Exome sequencing: sequencing exome regions (active regions of DNA; not introns).
Environment has big impact on molecular scale.
20 RNA’s per gene (21.000 genes) → 2.000.000 different protein forms.
- Glycosylation (sugar; glycan); happens to 80% of all proteins to be stable & to execute its
function.
➔ Role of molecular biomarkers in personalized healthcare = Personalized diagnosis,
personalized therapy, and personalized participation.
Precision medicine in genetic-metabolic disease; via genomic or metabolomics → new disease
mechanisms → personalized therapies.
- Role of molecular biomarkers: DNA, RNA, proteins, metabolites → X-omics → therapy
monitoring.
The future is more omic platforms (million data points), artificial intelligence, system biology → new
personalized therapies!
Future; stop looking at small parts, you would like to see the whole skeletal, instead of just a portion
of DNA you will see the whole stretch, long read
OMICS: you can go into metabolites, but also proteins
Voordelen van het kopen van samenvattingen bij Stuvia op een rij:
Verzekerd van kwaliteit door reviews
Stuvia-klanten hebben meer dan 700.000 samenvattingen beoordeeld. Zo weet je zeker dat je de beste documenten koopt!
Snel en makkelijk kopen
Je betaalt supersnel en eenmalig met iDeal, creditcard of Stuvia-tegoed voor de samenvatting. Zonder lidmaatschap.
Focus op de essentie
Samenvattingen worden geschreven voor en door anderen. Daarom zijn de samenvattingen altijd betrouwbaar en actueel. Zo kom je snel tot de kern!
Veelgestelde vragen
Wat krijg ik als ik dit document koop?
Je krijgt een PDF, die direct beschikbaar is na je aankoop. Het gekochte document is altijd, overal en oneindig toegankelijk via je profiel.
Tevredenheidsgarantie: hoe werkt dat?
Onze tevredenheidsgarantie zorgt ervoor dat je altijd een studiedocument vindt dat goed bij je past. Je vult een formulier in en onze klantenservice regelt de rest.
Van wie koop ik deze samenvatting?
Stuvia is een marktplaats, je koop dit document dus niet van ons, maar van verkoper rdeveer. Stuvia faciliteert de betaling aan de verkoper.
Zit ik meteen vast aan een abonnement?
Nee, je koopt alleen deze samenvatting voor €2,99. Je zit daarna nergens aan vast.
Is Stuvia te vertrouwen?
4,6 sterren op Google & Trustpilot (+1000 reviews)
Afgelopen 30 dagen zijn er 56326 samenvattingen verkocht
Opgericht in 2010, al 14 jaar dé plek om samenvattingen te kopen