Samenvatting van alle colleges gerelateerd aan MRI van blok BMS24: Medical Neuroscience van de Master Biomedical Sciences in Nijmegen. Handig voor het examen.
Structural MRI Describes shape, size and integrity of WM and GM in the brain. To indicate brain
structures. It visualise based on water and fat, not direct axons or neurons can be visualized.
Useful for highlighting lesions and pathologies
- FLAIR suppresses signal from fluids like CSF to highlight lesions
- DWI highlights areas of restricted water movement (strokes)
- fMRI detects change in blood flow which is used to study brain activation during tasks or
at rest
T1- weighted most often used to visualize WM and GM (white, gray)
T2 – weighted gets signal from CSF (white) and less from GM, WM (black/gray)
Bias
- Hardware related
o Signal to noise ratio higher is better
o Contrast to noise ratio
- Motion
MRI analysis
1. Brain extraction
2. Segmentation on tissue OR structure
3. Registration alignment making a common standard brain out of many brain type
Diffusion MRI measures water/CSF/blood/microstructure directionality and integrity in WM. Gets
info on anatomic connectivity and can go in many directions when scanning
Tensor = 3 dimensional ball that indicates how much water can diffuse in space of 3 dimensions
Strokes can be identified as following: because of the bleeding the tissue dies what makes CSF starts
flowing around can be identified with diffusion MRI
Image registration:
All brain images combined into 1 image
Essential for group study, fMRI or diffusion
Correction for motion
Quantifying structural change
Structural analysis VBM
Brain extraction = elimination of non-brain tissue
- Estimating the transformation and finding the transformation
- Resampling is applying a transformation, what means a new modified image that only
reduces image quality.
, Image spaces
- Reference coordinate system for reporting and describing
- In group study registered to standard space
- Talairach and Tournoux based on post mortem brain is a coordinate system that maps
the location of brain structures
- MNI template standard image based on non linear group average
FSL tools can move between different spaces
Different types of coordinate systems
- Voxel coordinates not aligned with anatomy, only with voxel
- Standard space coordinates axes aligned with anatomy
Spatial transformations: image transformed to become aligned
DOF = degrees of freedom
Rigid body 6 DOF 3 rotations and 3 translations, within subject motion
Non-linear 12 million DOF high quality image, local changes can be made in image
Affine 12 DOF Rigid body + 3 scaling and 3 skews/shears, need to initiatlize non linear,
lower quality imaging
Linear transformation makes image taller or thinner
Cost function = when are we good, goodness of alignment.
Interpolations: finds intensity values between grid points how to voxel value in new images
- Nearest neighbour assume missing voxels are value of a neighbour voxel
- Trilinear fills missing voxel by using average of voxels around
- Spline
- Sinc
- K-space methods
Physics:
Protons and neurons have their personal spin nuclei with odd numbers of protons and neutrons
net magnetic moment
Hydrogen
Properties of hydrogen
1. Resonance
a. Oscillation about magnetic field before settling
b. Time it takes is the resonance frequency
2. Excitation
a. Another magnetic field can get the ion out of its settling phase after resonance
b. Especially if this other magnetic field oscillates at the same resonance frequency =
DEFLECTION
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