Napqi - Samenvattingen, Aantekeningen en Examens

What is the MOA of acetaminophen? Not well understood - centrally acting - may block cytokines in the dorsal horn What are the actions of acetaminophen? Analgesic, antipyretic, raises pain threshold - is NOT anti-inflammatory What is the maximum daily dose of acetaminophen? 4g What are the indications for acetaminophen? Temporary relief of minor aches/pains and fever reduction What is a common danger about acetaminophen? There are a lot of combo products What can Tylenol do when taking...

Acetaminophen (APAP) toxicity is mediated by _________ . saturated normal liver conjugation pathways followed by insufficient glutathione to conjugate the metabolite NAPQI, which binds to hepatocellular proteins causing oxidative damange, mitochondrial dysfunction, and hepatocellular death What is the first step in acute overdose of acetaminophen? Metabolism by conjugation becomes saturated, and excess APAP is oxidatively metabolized by the CYP enzymes (CYP2E1, 1A2, 2A6, and 3A4) to t...

Identify the sources of acetaminophen exposure in cats and dogs. correct answers 1. Acetaminophen is present in more than 200 prescription and OTC formulations. 2. Most toxicoses result from well-meaning but ill-informed administration by owners. 3. Accidental ingestion of owner's medications. Why is acetaminophen not commonly used in cats and dogs? correct answers Low therapeutic index What is the level of plasma protein binding of acetaminophen? correct answers 1. Poor protein bin...

Foundations CBR20 – Toxicology Exam Questions With Complete Solutions How does activated charcoal work for decontamination and how should it be administered? High surface area binding to toxin and preventing systemic absorption. Dose: 10:1 (10g AC per 1g drug) When is activated charcoal contraindicated or ineffective? Contraindicated in AMS/obtunded patient, risk of seizure or aspiration, ileus. Ineffective for pesticides, lithium, hydrocarbons, heavy metals, alcohols, caustics. H...

Foundations CBR20 – Toxicology Exam Questions With Complete Solutions How does activated charcoal work for decontamination and how should it be administered? High surface area binding to toxin and preventing systemic absorption. Dose: 10:1 (10g AC per 1g drug) When is activated charcoal contraindicated or ineffective? Contraindicated in AMS/obtunded patient, risk of seizure or aspiration, ileus. Ineffective for pesticides, lithium, hydrocarbons, heavy metals, alcohols, caustics. H...

What is the MOA of acetaminophen? Not well understood - centrally acting - may block cytokines in the dorsal horn What are the actions of acetaminophen? Analgesic, antipyretic, raises pain threshold - is NOT anti-inflammatory What is the maximum daily dose of acetaminophen? 4g What are the indications for acetaminophen? Temporary relief of minor aches/pains and fever reduction What is a common danger about acetaminophen? There are a lot of combo products What can Tylenol do when taking...

Foundations CBR20 – Toxicology Exam Questions With Complete Solutions How does activated charcoal work for decontamination and how should it be administered? High surface area binding to toxin and preventing systemic absorption. Dose: 10:1 (10g AC per 1g drug) When is activated charcoal contraindicated or ineffective? Contraindicated in AMS/obtunded patient, risk of seizure or aspiration, ileus. Ineffective for pesticides, lithium, hydrocarbons, heavy metals, alcohols, caustics. H...

Identify the sources of acetaminophen exposure in cats and dogs. correct answers 1. Acetaminophen is present in more than 200 prescription and OTC formulations. 2. Most toxicoses result from well-meaning but ill-informed administration by owners. 3. Accidental ingestion of owner's medications. Why is acetaminophen not commonly used in cats and dogs? correct answers Low therapeutic index What is the level of plasma protein binding of acetaminophen? correct answers 1. Poor protein bin...

Foundations CBR20 – Toxicology Exam Questions With Complete Solutions How does activated charcoal work for decontamination and how should it be administered? High surface area binding to toxin and preventing systemic absorption. Dose: 10:1 (10g AC per 1g drug) When is activated charcoal contraindicated or ineffective? Contraindicated in AMS/obtunded patient, risk of seizure or aspiration, ileus. Ineffective for pesticides, lithium, hydrocarbons, heavy metals, alcohols, caustics. H...