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Explore topics like the risks of novelty, mechanisms of resistance, selective pressures, and adaptations in cancer suppression across species. Ideal for understanding cancer through the lens of evolution and genetics.

Comprehensive lecture notes covering simple traits, complex traits, genome scans, and QTL mapping. Explore key concepts, methodologies, and case studies like stickleback evolution, human height, GWAS, and more. Perfect for mastering the genetic basis of adaptation and evolution.

Lecture notes from Imperial College London, Biological Sciences BSc, 3rd year, Biodiversity Genomics (BG) module. These lecture notes explore the genetics of complex traits, focusing on the polygenic nature of these traits and the methodologies used to study them. It combines theoretical insights, case studies, and practical approaches, offering a comprehensive resource for understanding the genomic basis of traits influenced by many genes. Genome-Wide Association Studies (GWAS): Discusses G...

These lecture notes provide a detailed examination of the genetic basis of simple adaptive traits, highlighting key case studies and molecular mechanisms. The lecture notes explore how genetic mutations drive adaptation in natural populations and the methodologies used to uncover these associations, making it a valuable resource for understanding the genomic underpinnings of simple traits. Stickleback Pelvic Skeleton: A detailed case study on the three-spined stickleback (Gasterosteus aculea...

Lecture notes from Imperial College London, Biological Sciences BSc, 3rd year, Biodiversity Genomics (BG) module. These lecture notes provide an in-depth exploration of Quantitative Trait Locus (QTL) Mapping, a powerful tool in adaptation genomics for identifying the genetic basis of complex traits. The document combines theoretical foundations with real-world examples to illustrate the application of QTL mapping across diverse species and traits. Examples of QTL Mapping: C. elegans Stra...

Lecture notes from Imperial College London, Biological Sciences BSc, 3rd year, Biodiversity Genomics (BG) module. These detailed lecture notes provide a comprehensive guide to Adaptation Genomics, focusing on the principles and methodologies used in genome scans to detect and interpret signs of selection. A valuable resource for understanding the genetic basis of adaptation, the document covers key concepts, types of selection, and statistical methods used to analyse genomic data. Types of Se...

Lecture notes from Imperial College London, Biological Sciences BSc, 3rd year, Biodiversity Genomics (BG) module. This document synthesises research exploring cancer resistance and evolutionary dynamics in nature, with examples drawn from three influential papers. It offers an integrated perspective on how genomic innovations and evolutionary adaptations contribute to cancer resistance and ageing across diverse species. Content Overview: The Mystery of Cancer Resistance: A Revelation Wit...

Lecture notes from Imperial College London, Biological Sciences BSc, 3rd year, Biodiversity Genomics (BG) module. Detailed lecture notes on Cancer Selection provides a thorough exploration of the mechanisms driving cancer development, resistance, and evolutionary dynamics, offering critical insights for students. Part A: The Risks of Novelty Examines how evolutionary innovations, such as new body structures or life history traits, can increase cancer risks. Key topics include cancer adaptati...