Nucleophile - Samenvattingen, Aantekeningen en Examens

Mixtures have (higher/lower) melting points than pure substanceslower What is the purpose of sodium acetate solution in the amide synthesis of acetophenetidin?In the acylation reaction, the amine acts as a nucleophile, but we have the ammonium salt present in our solution. This ammonium salt can't act as a nucleophile (it doesn't have non-bonded electrons to use), so we need to add something to deprotonate the ammonium salt. This is the purpose of the sodium acetate - it is just a wea...

Reagent = Nucleophile Only - ANSWER1° = Sn2 2° = Sn2 3° = Sn1 + E1 (polar medium necessary) Reagent = Strong Nucleophile & Strong Base - ANSWER1° = Sn2 2° = E2 3° = E2 Reagent = Weak Nucleophile and Weak Base - ANSWER1°/2° = No Reaction 3°/resonance stabilized carbocation = Sn1 + E1 (polar medium necessry Reagent = Base Only - ANSWER1° = E2 or Sn2 (if unhindered and no beta-hydrogen with unhindered base) 2° = E2 3° = E2 Examples of Only Nucleophiles - ANSWERCl⁻, ...

Alkyl halides do one of two things when they react with a nucleophile/base, such as a hydroxide ion... - correct answer (1) undergo SUBSTITUTION of the X group by the nucleophile OR (2) undergo ELIMINATION of HX to yield an alkene carbon-halogen bonds in alkyl halides are polar and the carbon atoms are electron-poor, thus, alkyl halides are ELECTROPHILES Nucleophilic Substitution Reactions - correct answer -each st...

Basicity rules - -strong base: unstable/reactive (ED groups) -weak base: stable (EW groups/more EN/bigger) Chair conformation - -more stable equitorial (slanted) -pointing up/pointing down=cis if both up -elimination: trans and diaxial Newman projection - -gauche: substituent groups adjacent to eachother -grab middle and turn to put in plane Enantiomers - -not superimposable mirror images -same besides stereochemistry Diastereomers - -mirror images but one stereocenter stays and...

Nucleophile ֎ -:- A species that donates a lone pair of electrons. Examples include ammonia, water and cyanide. Electrophile ֎ -:- A species that accepts a pair of electrons. The most common example is H+ that accepts a lone pair of electrons from a nitrogen atom in ammonia. Nucleophilic substitution ֎ -:- A substitution reaction in which a nucleophile such as ammonia is attracted to a positive charge centre such as the functional group carbon atom of a halogenoalkane. Hydrolysi...

MCAT Organic Chemistry Exam Questions and Answers Instantaneous Dipole Moment - Answer-Exists in an otherwise nonpolar molecule. Occurs because the electrons in a bond move about the orbital and at any moment may not be distributed exactly between the two bonding atoms, even when the atoms are identical. London Dispersion Forces - Answer-Occur between two instantaneous dipoles; the weakest dipole-dipole force (vs. hydrogen bonds which are the strongest dipole-dipole forces). Wolff-Kishner...

SN1 Reaction - ANSWER- Unimolecular nucleophilic substitution - 2 steps - Starting with enantiomerically pure product tends to result in some degree of racemization - Retention AND inversion at stereocenter (R and S) - 1 nucleophile is replaced by another nucleophile - Carbocation INTERMEDIATE forms - Rate is dependent only on substrate concentration 1. LG leaves, forming a carbocation 2. Nucleophile attacks the carbocation, forming the product SN2 Reaction - ANSWER- Bimolecular nuc...

IB Organic Chemistry (HL) Latest Update 100% Solved chiral carbon A carbon that is singly bonded to 4 different atoms forming a tetrahedron that forms non-superimposable mirror images homolytic fission breaking a bond where each electron in a bond goes to one atom heterolytic fission breaking a bond where both electrons in a bond goes to one atom homologous series A series of molecules that have the same general formula but differ by the number of CH2's, has similar chemical ...

DAT Organic Chemistry Review Practice Test. Which are more stable conformers - CORRECT ANSWER staggered What are the rate laws of SN2 and E2 reactions - CORRECT ANSWER rate= k [RX][Nu:-] rate depends on concentrations of alkyl halide and nucleophile What are the rate laws of SN1 and E1 reactions - CORRECT ANSWER rate= k[RX] rate only depends on the concentration of the alkyl halide E2 elimination reactions must occur in bonds that are - CORRECT ANSWER coplanar or antiperiplan...

UMICH CHEM 210 - Exam #3 - Reaction Mechanisms 100% Correct SN1 Reaction - ANSWER- Unimolecular nucleophilic substitution - 2 steps - Starting with enantiomerically pure product tends to result in some degree of racemization - Retention AND inversion at stereocenter (R and S) - 1 nucleophile is replaced by another nucleophile - Carbocation INTERMEDIATE forms - Rate is dependent only on substrate concentration 1. LG leaves, forming a carbocation 2. Nucleophile attacks the carbocati...