High-yield Pharmacology notes on the fundamentals of Pharmacokinetics which describes the process of Absorption, Distribution, Metabolism and Excretion.
A colourful, simplified, high-yield compilation of Pharmacology notes packed with mnemonics and summaries to make it as easy as possible to rem...
2) The drug is liberated/ released from its
pharmaceutical form (capsule, tablet,
suppository etc)
Presentation by F.Khan 2021
,Pharmacokinetics
Important Point
Watery molecules: easier to excrete
Fatty molecules: difficult to excrete, easier to
get into body cells (it’s easy to store fat)
Presentation by F.Khan 2021
,Pharmacokinetics: Excretion
ionized
Presentation by F.Khan 2021
,Pharmacokinetics
ADM
1) Absorption
The process where a drug is transported from the
site of administration to systemic circulation (blood
circulation) by crossing a biological membrane.
Factors affecting absorption
• Bio-availability:
- First Pass Effect
- Enterohepatic recycling
- Solubility
• Concentration of the drug
• Surface area of absorption site
• Blood supply of absorption site
• Gastric Emptying
Presentation by F.Khan 2021
,Pharmacokinetics
Simple Explanation:
From site of administration to bloodstream.
The drug enters the body then crosses a
membrane/ barrier to get into the blood stream to
be distributed to its target tissue.
Eg. A drug enters the stomach and has to cross the
cells making up the stomach lining to enter the
blood stream.
Presentation by F.Khan 2021
, Pharmacokinetics AD
1) Bioavailability Bioavailability is affected by:
Route of administration: drugs de
Bioavailability refers to the extent and rate in through IV routes are 100% bioavai
which the active drug metabolites enters Drugs absorbed directly into bloods
systemic circulation, thereby accessing the site have higher bio-availablity compare
of action. It is the basically fraction of the dose drugs that go through first-pass met
which reaches systemic circulation.
First-Pass Effect: Metabolism of or
administered drugs in the liver befor
reaches systemic circulation.
Solubility: The ability of a drug to p
through the phospholipid cell memb
depending on the nature of the subs
Presentation by F.Khan 2021
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