100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
MindMap of DNA Mutagenicity, Damage and Repair (MCB2023) R133,00   Add to cart

Other

MindMap of DNA Mutagenicity, Damage and Repair (MCB2023)

 6 views  0 purchase

Comprehensive MindMap summary of the DNA Damage and repair block.

Preview 1 out of 4  pages

  • November 8, 2021
  • 4
  • 2021/2022
  • Other
  • Unknown
All documents for this subject (11)
avatar-seller
mattclothier13
- Hydroxylamine (NH2OH)
- Reacts with C (hydroxylation)
- Hydroxylated C pairs with A (CG-TA transition)
- Alkylating agents:
- Transfer alkyl groups (methyl, ethyl) to bases
- Alkylation of guanine results in
9-methylguanine (AlkG)
- AlkG pairs with T (GC ? TA transition)




- Cause inaccurate base paring
- Sometimes used in cancer and anti-viral therapy
- Adenine analogue = 2 amino purine (2AP)
- Substitutes A, (causing AT-GC transition) and
base pairs with C
- Thymine analogue = 5 Bromouracil (5BU)
- Substitutes T, (causing AT-GC transition ) and
base pairs with G


- Bases typically exist in the amino/
but can take on either imino or en
- Tautomeric forms allow for transiti
mutations to occur.
- Can occur via changes of pH




Tautomerism


- Loss of purines -> apurinic sites Insertion of DNA via
- Apurinic site don't base pair normally & Mobile Genetic
DNA Pol may insert wrong base Elements
- = Transition or Transversion after replication
or deletion
- Base loss results in ?ring opening?in the
sugar moiety causing weaking of the DNA
Depurination
backbone = strand breaks.
- Typically 1 in 105 purines are lost from DNA
every 24 hours

- Information on the DNA strand is not

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through EFT, credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying this summary from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller mattclothier13. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy this summary for R133,00. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

82105 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy summaries for 14 years now

Start selling
R133,00
  • (0)
  Buy now