Pharmaceutical technology and biopharmacy 1, Nederlandse samenvatting
Pharmaceutical technology and biopharmacy 1, Nederlandse samenvatting
Pharmaceutical technology and biopharmacy 1, Nederlandse samenvatting
Pharmaceutical technology and biopharmacy 1, Nederlandse samenvatting
Pharmaceutical ...
Ph
arma
ceu
tic
alt
ech
nol
ogya
ndb
iop
har
mac
y1:
Doser
ingsvorme nz i
jnontworpe
nmetb i
ofar
maceuti
schee n
tec
hnologi
s c
h ed oel
s t
el
li
ngend i
eku
nnenwor d
env e
rkreg
e nvi
a
doser
ingsvorme ning eda
c ht
en.Def
ormulebesch
rij
ftdekwali
tat
ie
ve
enkwan t
it
ati
e vec ompositi
evandevor
m, ookdestr
u c
tuurvande
vor
m.
Dedoseri
ngs vormza l1ofme er
deretherapeuti
schesubst
anti
es
beva
ttenme te e
nb epaaldehoevee
lheidhu l
pstof
fen.Hul
pst
offen
kunne
nf unc
t i
o n
a l
i
teit
entoevoegena a
nd ose r
ing
svormenz i
jn
bel
angri
jkomb i
ofarma c
eu t
is
cheent echnol
og i
schedoel
stel
li
ngente
ber
eike
nd i
ev e r
kregenzull
enmoe t
e nword enbij
doseri
ngsvor
m. De
fu
ncti
onali
teitvand edoseri
ngsvor
mi sb epaaldbi
jzowelde
samenstel
l
inga lsstru
c t
uurvandoseri
n g
sv orm.
Bi
ofar
mac
euti
sch
edoe
lst
el
li
nge
n:
re
lea
sepr
ofi
l
e
r
outevantoe
d i
eni
ng(bep
a a
lddes
tru
ctuu
rva
ndos
eri
ngs
vor
mend
e
e
isenwaaraandose
rin
gsvormmoetv
old
oen)
t
arg
e t
ing
Deinn
ovat
iei
nbi
ofa
rmace
uti
sch
edoe
lst
el
li
ngenis
ged
revend
ooron
twi
kke
li
ngeni
nmedi
ci
jnt
her
apie
.
Tec
hnologi
schedoel
st
ell
in
gen(v
aakkwal
i
tei
tens
tab
il
it
ei
ten
mogel
ij
khedenpr
o d
ucti
evansp
ecif
iek
evor
mineenf
ormul
e):
con
tro
lere
nv anp
roces
,s
tab
il
it
ei
t
r
epr
oduce
erb
aar
hei
d
Str
uctuuri
sb e
lan
grij
k,d
es tr
uctu
urvandoser
ing
svormdiev
aakde
func
ti
on al
i
tei
tbepaal
dva ndoser
ing
svor
m. I
nnovat
ie
sin
tec
hnologi
schedoels
tel
li
ngenvandoser
ing
svormenzij
ngedr
eve
n
doorte
c hn
ologi
scheontwik
keli
ngen.
Pr
od u
c t
iemoe tvol
doenaanh ogekwali
tei
tsei
senenv e
rzek
erend a
teen
ef
fect
ief,v
eil
igenb et
rouwbaarme d
ici
jnpr
oductwordtgepr
oduceerdin
eenrepr
o duce
e r
barema n
ier
.Opd ezema ni
erwordtdoser
ings
vorm
gepr
oduc e
erd,kandire
ctaanp at
ië
ntwor d
eningedie
ndofme tbehulp
va
ne ena ppar
aat(bij
v.naal
d).Ennatoedi
eninghopenopthera
p eut
is
ch
ef
fect
. Ef
fectnie
talle
enb epaa
lddoorme di
cij
nsubst
anti
esma arook
doordoseri
ngsvormwa ar
me eme di
ci
jntoegedi
endis.
, l
OMo
ARc
PSD|
116
297
41
Ther
apeuti
schewe rk
zaamheidvanme dic
ij
nsubst
ant
ieisbepaal
ddoor
:
I
ntr
insi
ekefarmalogi
scheentoxic
ologis
cheeige
nschappenvan
s
ubstanti
e(rec
ep t
orin
ter
acti
e).
Omvange nsnel
he i
dvanlev
erenvans ubst
ant
ieaankantvanact
ie,
b
epaaldebij
:
Deomvan gensne l
hei
dvanvrij
kome nmedici
j
nvando s
e r
ings
vor
m
Depla
atsv anafgi
ft
ev a
nme dic
ij
nsub s
tant
ieui
tdoser
ingsvor
m.
Tr
ansportvanme di
cij
nsub
stanti
evanp l
ekvanadsor
p t
ienaarpl
ekvan
act
ie.
Punt
en1,2
,3zi
jnb
epaal
ddoor
:
Fy
sicoc
hemis
cheeig
ensc
happ
env
anme
dic
ij
nsu
bst
ant
ie
Functi
onel
easpec
tenv a
ndoseri
ngsv
orm( st
ruc
tuu
ren
fy
sicoche
mischeaspe
c t
envandoser
ingsvor
m)
Pl
ekv anvr
ij
la
tenmedici
jnui
tdoser
ings
v or
m
Deroutevanmedi
cij
ntoedi
eni
ngdievoorbepaa
ldmed
ici
j
nisg
eko
zen
Gr
ote
nde
elsb
eïn
vloe
dofb
epa
aldd
oord
ose
rin
gsv
orme
nst
ruc
tuu
r!
Dec onst
a n
tevand i
s s
olut
iep r
oc esend athetmedici
j
no pl
os ti
n
l
ich
a ami sbel
angrij
k.All
eenop gelosteme di
cij
nenkunnend oor
memb raneneninteract
ieheb benme teenreceptor
.Duse e
nme di
ci
jn
moetz i
jnopgel
os tvoorhetwa tkand oen,bi
jnageenéénme di
ci
jn
doetiet
swa nneerhetnoginv astes t
aatis.Eenopl
ossingise e
n
st
abielemolecul
airesprei
dingv anme di
cijni
ne enconti
numa t
ri
x
bev
a tt
endu i
teena nderma t
e r
iaal(wate
rofa nderopl
osmidd el
).
Omd atme di
ci
jn
e nslechtoplosseninv l
oeist
offe
ninli
chaam, isdi
tde
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