UNE Biochem 1005 Unit 2 exam Questions With Complete Solutions
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Course
CHEM 1005
Institution
University Of New England (UNE
)
1. Pyruvate dehydrogenase kinase catalyzes a reaction that results in which of the following? correct answer: The phosphorylation and inactivation of E1 subunit (pyruvate dehydrogenase complex
1. Which of the following intermediates is an allosteric activator of pyruvate kinase? correct answer:...
une biochem 1005 unit 2 exam questions with comple
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University of New England (UNE
)
CHEM 1005
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UNE Biochem 1005 Unit 2 exam Questions
With Complete Solutions
1. Pyruvate dehydrogenase kinase catalyzes a reaction that
results in which of the following? correct answer: The
phosphorylation and inactivation of E1 subunit (pyruvate
dehydrogenase complex
1. Which of the following intermediates is an allosteric activator
of pyruvate kinase? correct answer: a. Fructose 1.6
bisphosphate
1. Which of the following is the initial second messenger in the
signaling cascade initiated by glucagon? correct answer: a.
cAMP
1. Hereditary fructose intolerance in caused by a deficiency in
aldolase B. These individuals may present with hypoglycemia
due to an accumulation of fructose 1-P in the cell and inhibition
of which of the following pathways? correct answer: a.
Gluconeogenesis and glycogenolysis
1. Following insulin binding its receptor and
autophosphorylation of the beta chain, what is the initial step in
the cascade of events? correct answer: a. Recruitment of the
insulin receptor substrate
1. What sequence of enzymes allows for the synthesis of
glycogen from glucose 6-P? correct answer:
1. Complex II, succinate dehydrogenase, is not considered to be
part of the process of oxidative phosphorylation because it is
unable to do which of the following activities? correct answer:
a. Pump protons from the mitochondrial matrix to the
intermembrane space
1. Which of the following is the primary GLUT transporter in
skeletal muscle and adipose tissue? correct answer: GLUT 4
1. Which of the following best describes the net effect of the 8
steps of the TCA cycle? correct answer: a. This process
completely oxidizes an acetyl group to carbon dioxide
1. Which of the following enzymes is correctly paired with this
activator? correct answer: a. Pyruvate dehydrogenase complex,
pyruvate
1. ATP is a high energy molecule that is often hydrolyzed during
reactions. The energy within ATP is stored primarily in which of
the following compounds of the molecule? correct answer: a. In
the high energy phosphate bonds
1. Which of the following is a key inhibitor of the a-
ketoglutarate dehydrogenase? correct answer: NADH
1. As electrons flow through complexes in the inner
mitochondrial membrane, protons are pumped from the matrix
to the intermembrane space. Which of the following statements
, is most reflective of the pH in the intermembrane space? correct
answer: a. The pH is higher in the matrix when compared to the
intermembrane space
1. Pyruvate dehydrogenase complex is highly regulated. The
enzyme will be most active when which of the following
compounds is high? correct answer: Pyruvate
1. TCA cycle intermediates are always being removed for
various metabolic processes. One example of this is the removal
of succinyl CoA which is used for the synthesis of which of the
following compounds? correct answer: Heme
1. The fully reduced quinol form of CoQ contains which of the
following combinations of electrons and protons? correct
answer: 2 e- and two protons
1. Individuals with a deficiency in glucose 6-P dehydrogenase
often present with hemolytic anemia. This is primarily due to a
deficiency in which of the following metabolic products? correct
answer: NADPH
1. Within the red blood cell, glucose can be oxidized to which of
the following products? correct answer: lactate and ribose 5-
phosphate
1. Which of the following is an inhibitor of isocitrate
dehydrogenase and a-ketoglutarate dehydrogenase? correct
answer: a. NADH
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