UNE BioChem 1005 - Unit 2 review| 154 Questions| With Complete Solutions
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Course
CHEM 1005
Institution
University Of New England (UNE
)
Which of the following reactions is commonly used to replenish intermediates of the citric acid cycle? correct answer: glutamate --> ketoglutarate
Which of the following statements is true regarding the activity of the ribonuceltide reductase? correct answer: The enzyme is required to conve...
UNE BioChem 1005 - Unit 2 review| 154
Questions| With Complete Solutions
Which of the following reactions is commonly used to replenish
intermediates of the citric acid cycle? correct answer: glutamate
--> ketoglutarate
Which of the following statements is true regarding the activity
of the ribonuceltide reductase? correct answer: The enzyme is
required to convert nucleotides from the ribose form to the
deoxyribose form required for DNA synthesis
A Southern blot with a probe (denoted as XXXX in the figure)
to DNA isolated from an individual who has both a mutant and a
recessive allele would produce which of the following results?
correct answer: DNA fragments of a molecular weight of 1.2kb
and 0.9 kb
Under anaerobic conditions, the glucose is primarily oxidized to
which of the following compounds? correct answer: Lactate
A mutation occurs deleting 9 base pairs in a coding region of the
genome. It is downstream of both a transcriptional and
translational start site. Assuming protein translation was not
impacted by this insertion, comparison of a western blot of
samples collected from individuals carrying this deletion to
samples from control individuals without this deletion would
show: correct answer: The Western Blot of samples from the
,individuals with the deletion would show proteins with a
decrease in molecular weight
The order of prosthetic groups as they act in the three proteins of
the PDC(pyruvate dehydrogenase complex)is: correct answer:
thiamine pyrophosphate → dihydrolipoamide → FAD
Hemoglobin has the ability to display cooperative binding. The
property of cooperative binding is only displayed by proteins
that have __________________ structure. correct answer:
quaternary
See page 97. Quaternary structure increases protein stability,
enables a protein to exhibit cooperative binding or to form
binding sites with a high affinity for large molecules.
The fully reduced quinol form of CoQ contains which of the
following combinations of electrons and protons? correct
answer: two electrons and two protons
A mutation occurs inserting a single base pair into a coding
region of the genome. It is upstream of the translational start site
but downstream of the transcriptional promoter. What impact
will this have on the mRNA transcript when compared to the
normal message? correct answer: the transcript will be longer
If the insertion is DOWNSTREAM of the transcriptional start it
would be incorporated into the transcript and the transcript
would be LONGER.
, Damage of a single base (such as deamination) leading to small
distortions in the DNA helix are repaired by which of the
following mechanisms? correct answer: base excision repair
DNA is a double helix and the nucleotides form complementary
hydrogen bonds to stablize this structure. If a stretch of DNA
has the following sequence 5' AAC TTC GGC 3' what is the
nucleotide sequence of the complementary strand? correct
answer: 3' TTG AAG CCG 5'
A deficiency in B6 (pyridoxal phosphate) would negatively
impact which of the following pathways:
1. transsulfuration of homocysteine
2. remethylation of homocysteine
3. the folate cycle correct answer: 1 only - 1. transsulfuration of
homocysteine
The Epo receptor is an example of a classical Jak - STAT type
of receptor. All of the following are true statements with regards
to this receptor family except: correct answer: Signaling can be
terminated through activation of phosphodiesterase
(true statement: Signaling can NOT BE terminated through
activation of phosphodiesterase)
Glucokinase has a higher Km than hexokinase. Which of the
following accurately describes the activity of glucokinase with
respect to the enzymes Km? correct answer: Glucokinase will
be less active then hexokinase at low concentrations of glucose.
Aldolase B facilitaes a reaction that cleaves fructose 1-
phosphate into dihydroxyacetone-phosphate and what other
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