ASCP: Hematology Polansky Cards questions and answers 100% verified. Erythropoiesis: Yolk sac & aorta -gonads -mesonep hros (AGM) region - correct answers.1 -2 mo of gestation - Primitive erythroblasts. Embryonic hemoglobin Erythropoiesis: Liver, spleen - correct answers.3 -6 mo of gestation -Liver is primary site Erythropoiesis: 7 mo of gestation —age 4 yr - correct answ ers.Bone marrow. All marrow is active Erythropoiesis: Adult - correct answers.bone marrow -only active sites are Skull, Ribs, Sternum, Vertebrae, and Pelvis - the shafts of the long bone are filled with fat (the fatty marrow may be reactivated to compensate for anemia) Changes During Cell Maturation: Cytoplasm Less basophilic due to loss of ---. Granulocytes produce granules. Erythrocytes become pink due to ---- production. - correct answers.Changes During Cell Maturation: Cytoplasm -Less basophilic due to loss of RNA. Granulocytes produce granules. Erythrocytes become pink due to Hgb production. Changes During Cell Maturation: Nucleus -Becomes smaller. Nu clear chromatin ----. Nucleoli disappear. In granulocytic series, -- indents, then segments. In erythrocytic series, the --- is extruded. - correct answers.Changes During Cell Maturation: Nucleus -Becomes smaller. Nuclear chromatin condenses. Nucleoli dis appear. In granulocytic series, nucleus indents, then segments. In erythrocytic series, nucleus is extruded. RUBRIBLAST TERMINOLOGY: Rubriblast - correct answers.Pronormoblast - N:C ratio 8:1. Royal blue cytoplasm. -Fine chromatin. -1-2 nucleoli. Centr al -Normally confined to bone marrow. RUBRIBLAST TERMINOLOGY: Prorubricyte - correct answers.Basophilic normoblast -N:C ratio 6:1. -Chromatin is coarser with slightly visible parachromatin. -Nucleoli usually not visible. -Normally confined to bone marrow. RUBRIBLAST TERMINOLOGY: Rubricyte - correct answers.Polychromatophilic normoblast: The Last stage to divide. -N:C ratio 4:1. -Cytoplasm is polychromatophilic due to hemoglobin production. -Chromatin is clumped with distinct areas of parachromatin. -Normally confined to bone marrow. -Note that the cytoplasm color is now a blue/gray rather than the deep midnight blue of the basophilic pronormoblast stage. RUBRIBLAST TERMINOLOGY: Metarubricyte - correct answers.Ortho chromic normoblast: -Last nucleated stage. N:C ratio 1:2. Nucleus is pyknotic. -Normally confined to bone marrow. RUBRIBLAST TERMINOLOGY: Reticulocyte - correct answers.Polychromatophilic erythrocyte :No Nucleus -Cytoplasm is diffusely basophilic (blui sh tinge). -Reticulum seen with supravital stain. -0.5% -1.5% of RBCs in adult peripheral blood. Slightly immature, non -nucleated red cells (reticulocyte stage) appear blue -gray on Wright -
stained smears due to the presence of residual ribonucleic acid (RNA). These cells are referred to as polychromatophilic cells. Polychromatophilic cells are frequent ly larger in size than mature red cells and can be distinguished from macrocytes by their distinctive blue -gray color RUBRIBLAST TERMINOLOGY: Mature erythrocyte - correct answers.Mature erythrocyte (RBC) -Biconcave disk. -Reddish -pink cytoplasm with ar ea of central pallor 1/3 diameter of cell. Where maturation rate of nucleus is not occuring at the same rate as the cytoplasmic maturation. - correct answers.Asynchronous Erythropoiesis Asynchronous Erythropoiesis: Cause: Vitamin B12 or folic acid defic iency Example: Explanation: Characteristics: - correct answers.Type: Megaloblastic Example: Pernicious Anemia Explanation: Nucleus lags behind cytoplasm in maturation. Cells grow larger without dividing Characteristics: Oval macrocytes Asynchronous Erythropoiesis: Cause: Iron deficiency Example: Explanation: Characteristics: - correct answers.Asynchronous Erythropoiesis: Example: Iron deficiency anemia Explanation: Cytoplasm lags behind nucleus in maturation due to inadequate iron for hgb synthesis Characteristics: Microcytic, hypochromic RBCs What Type of Hemoglobin? 2α , 2 β chains - correct answers.Hemoglobin A Adults: > 95% Newborn: 20%
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