Other
Abstract topic 5 - Breath and Feces Analysis
- Course
- Institution
This is the abstract for the topic 5. It was graded first a PASS and then a GOOD. Hope it helps!
[Show more]
Seller
Follow
BetterCallSaul123
Content preview
Investigating the differences of breath profile between males and females usingprincipal component analysis
Name ID
Bachelor Biomedical Science, BBS2003, Maastricht University, Maastricht, The
1
Netherlands
Purpose:
Principal component analysis is a multivariate technique that is based on variance,
and it is used for analyzing and determining relationships in very large datasets. Such
datasets are generated in the exhaled breath field. The aim of the study is to
investigate the differences in breath profile in males and females.
Materials and Methods:
Exhaled breath samples were collected from 50 healthy individuals (25 males, 25
females), via the use of tedlar bags. The content of exhaled breath was then measured
via the use of thermal desorption, followed by the use of gas chromatography- time-
of-flight mass spectrometry (GC-tof-MS). In the end, breath chromatograms were
generated and the trend in the data was examined using principal component analysis
(PCA).
Results:
Out of all the sampled compounds, 33 different breath volatile organic compounds
(VOCs) were found to be statistically significantly different among males and females
(p<0.001). Initially, the breath profiles showed some separation between males and
females, however some overlap was recorded between subjects. When only the
significant compounds were considered, complete separation was achieved.
Conclusions:
Differences in significantly different volatile compounds can be assessed using PCA
analysis. PCA could serve as a potential tool with clinical use to help describe
differences in VOCs or other sexually dimorphic characteristics in males and females,
thus limiting bias in future research of diseases.
Keywords: principal component analysis (PCA), males vs females, exhaled breath,
big data
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through EFT, credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying this summary from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller BetterCallSaul123. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy this summary for R72,78. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
76799 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy summaries for 14 years now