I will soon have my Masters in Genetics and I completed my honours in Clinical Pharmacology. The pharmacology was course work on it's own, so the summaries are very well written and easy to learn. If you have Pharmacology, you will know that it is a lot of work to get in your mind in a short amount...
Ionisation
IONISED
POLAR
Water-soluble
Lipophobic
Hydrophilic
Do not cross membranes readily
ACIDIC drugs bind to ALBUMIN
ACIDS are ionised in BASIC media
BASIC drugs bind to α1-GLYCOPROTEIN
BASES are ionised in acidic media
UNIONISED
NON-polar
Fat soluble
Hydrophobic
Lipophilic
Diffuse more readily across a membrane
Very HIGH L-WDC
Distributes widely through the body
Acts in the CNS (crosses the bbb by PASSIVE DIFFUSION)
Weak ACIDS
HA A- + H+
¿ IONISED
pH= pKa + log10 A− HA ¿ Ratio = UNIONISED
With a dissociation constant K
a
Weak BASES
BH+ B + H+
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