100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Previously searched by you
Previously searched by you
logo
Summary Bradykinin explained R110,00   Add to cart
Quickly navigate to
Preview
  2.  
  3. University Of Pretoria (UP)
  4.  
  5. Pharmacology

Summary

Summary Bradykinin explained
 62 views  0 purchase

I want to help you get through all the different drug classes in Pharmacology. I have found that students struggle to get through the amount of work. These summaries helped me get through my Honours Degree. I will soon graduate with my Masters of Science in Neurogenetics. You got this!

Preview 2 out of 7  pages

Document information

  • Yes
  • June 19, 2019
  • 7
  • 2014/2015
  • Summary

Subjects

Connected book

book image

Book Title:

Author(s):

  • Edition:
  • ISBN:
  • Edition:

More summaries for

All for this textbook (26)

Written for

All documents for this subject (17)

Seller

avatar-seller
chanbain

Content preview

PRINCIPLE 1: BINDING
 Specific targets of drug action
 Drug action is explained in terms of CONVENTIONAL
CHEMICAL INTERACTIONS
 Low [D] still involve large numbers of molecules
 Avogadro’s number = number of molecules found in 1 mole
of a substance
 1 drop of a [D] = 10-10 mol/l contains 1010 drug molecules

 Drug molecules must get so CLOSE to other molecules
that they exert a CHEMICAL INFLUENCE on them

 Drug distribution = at random,
interaction (with particular cellular molecule) = negligble
D/R INTERACTION:
 Depends on [D] and [R]
 D-R amount determines the RESPONSE MAGNITUDE
 Threshold: minimum number of D-R complexes 
response
↑ [D]  ↑D-R  ↑ EFFECT
SATURATION = NO FURTHER ↑R
 LAW OF MASS ACTION APPLIES TO D-R INTERACTION
 A DRUG WILL NOT WORK UNLESS IT IS BOUND!!

, TARGETS OF DRUG ACTION:
1) SIMPLE CHEMICAL NEUTRALISATION - antacid
2) ENZYME INHIBITORS – antibiotics
o Inhibitor  normal reaction INHIBITED
o False substrate  ABNORMAL METABOLITE produced
o Pro-drug  ACTIVE drug produced
3) R OCCUPYING DRUGS – related to NTs
o Agonist  direct  ion channel OPENING/CLOSING
o Agonist  transduction  Enzyme +/-, ion channel
modulation, DNA transcription

o Antagonist  NO EFFECT, endogenous mediators BLOCKED

4) MODULATORS OF CERTAIN TRANSPORT SYSTEMS –
Na+/K+-ATPase

o NORMAL TRANSPORT
o Inhibitor  transport BLOCKED
o False substrate  ABNORMAL COMPUNDS accumulate

5) ION CHANNEL INTERACTION – local anesthetics

o Blockers  permeation BLOCKED
o Modulators  ↑/↓ opening

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through EFT, credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying this summary from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller chanbain. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy this summary for R110,00. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

81113 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy summaries for 14 years now

Start selling
R110,00
  • (0)
  Buy now