· Absence of known causes of hypoventilation (it is not caused by neuromuscular,
mechanical, or metabolic causes)
What kind of lung disease is present in individuals with obesity? - ANSWER A
restrictive lung disease; the larger chest wall and increased abdominal pressure
create an extrinsic restrictive state
What cardiovascular comorbidities present with obesity? - ANSWER 1. Ischemic
heart disease
2. HTN
3. Cardiac failure
4. Total blood volume is increased, but the volume-to-weight ratio is less than in
non-obese individuals (50 mL/kg)
5. Higher metabolic demand (greater O2 consumption and CO2 production)
6. Hypercoagulable and in a pro-inflammatory state (peripheral and coronary artery
disease are more likely to occur)
How does the volume of distribution change in obese individuals? - ANSWER 1.
Relative total body water is reduced (40% compared to 60%)
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