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HMX LYMPHOCYTE DEVELOPMENT AND DIVERSITY – QUESTIONS & SOLUTIONS
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HMX LYMPHOCYTE DEVELOPMENT AND DIVERSITY – QUESTIONS & SOLUTIONS
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HMX LYMPHOCYTE DEVELOPMENT AND DIVERSITY –QUESTIONS & SOLUTIONS
Which of the following is an accurate statement about antibody recognition of
antigen? Right Ans - Antibodies can recognize any class of molecule outside
of cells.
The adaptive immune system is responsible for coordinating a specific
response to microbes, in contrast to the innate immune system, which
provides a rapid, but generalized, response. Which of the following is NOT a
challenge that the adaptive immune system must overcome to mount a
specific response to a microbe? Right Ans - Lymphocyte receptors are not
sufficiently diverse to recognize all possible microbes.
Expansion Right Ans - Clonal selection describes the interaction between
microbial antigen and its specific lymphocyte receptor, while clonal ____________
describes the proliferation of the lymphocyte in response to the antigen-
receptor interaction.
Which of the cells, below, arise from the common lymphoid progenitor (CLP)?
Right Ans - NK cells,B cells
stem cell Right Ans - A cell that can undergo self-renewal and differentiate
into any of the cells of the blood is called a hematopoietic ____________.
Granulocytes Right Ans - Neutrophils, eosinophils, and basophils are all
examples of ____________, which are cells that have many granules in their
cytoplasm.
bone marrow Right Ans - Consider the anatomical locations of blood cell
development. The earliest stages of HSC differentiation occur in the
____________.
At a certain stage in B cell development, the developing B cells move to
lymphoid tissues. This occurs at which stage of differentiation? Right Ans -
immature B cell
, At which stage of development do B cells first express immunoglobulin (Ig)
heavy chains? Right Ans - pre-B cell
thymus Right Ans - At the pro-T cell stage, differentiating T cells migrate to
the ____________, the site of all subsequent stages of T cell development.
What structure binds to the T cell receptor? Right Ans - a peptide bound to
an MHC protein
Cytotoxic T cells (CTLs) are a subset of T cells that express the molecule CD8
on their cell surface and contain granules filled with proteins that can cause
death to infected cells. In the right circumstances, when they bind to antigen
they will release these granule contents as a "lethal payload." The granule
contents induce apoptosis in the cell that displays the antigen.
What type of pathogen cannot be controlled by CTLs? Right Ans - bacteria
that replicate outside of cells
In a previous lesson, you learned about antibody structure. Which portion of
the antibody light chain protein contains the antigen binding site? Right
Ans - the N-terminus, which contains the variable region
In human cells, there are approximately 45 V segments, 23 D segments, and 6 J
segments in the Ig heavy chain gene region.
How many possible heavy chain proteins can be created from these different
segments, simply due to combinatorial diversity?
Please enter an exact number. Right Ans - 6210
The immunoglobulin light chain does not have a D segment. In humans, there
are two different possible light chain proteins, termed kappa and lambda.
Assume that there are 35 V segments and 5 J segments in the human kappa
light chain region, and there are 30 V segments and 4 J segments in the human
lambda light chain region.
How many possible light chain genes can be created from these different
segments, simply due to combinatorial diversity?
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