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HMX Pharmacology Definitions – Complete Guide
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HMX Pharmacology Definitions – Complete Guide
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HMX Pharmacology Definitions – Complete GuideThe uptake of a drug from its site of administration into the bloodstream.
Right Ans - Absorption
The movement of a molecule against its concentration gradient across a
membrane, with a concomitant expenditure of energy. Right Ans - Active
transport
A measure of the strength of drug-receptor binding. Right Ans - Affinity
An endogenous or exogenous ligand that binds to and stimulates a receptor to
produce a molecular response. Right Ans - Agonist
A reaction involving synthesis of new molecules, generally requiring energy
Right Ans - Anabolic reaction
An endogenous or exogenous molecule that binds to and blocks a receptor to
inhibit a molecular response. Right Ans - Antagonist
A glycoprotein that plays an important role in the immune response by
binding to and targeting specific antigens for removal from the body Right
Ans - Antibody
A substance, generally foreign to the body, that induces an immune response.
Right Ans - Antigen
When the concentration of drug in the plasma is plotted over time on a graph,
the AUC is used as a measure of the total exposure of the body to a drug.
Right Ans - Area under the curve (AUC)
Specialized glial cells in the brain that contribute to the integrity of the blood-
brain barrier. Right Ans - Astrocytes
The molecular response produced by a receptor in the absence of a bound
ligand, also referred to as constitutive activity. Right Ans - Basal activity
, A graph representing the percentage of receptor occupancy, or the percentage
of receptors bound by a drug, plotted against the concentration of drug at the
receptor. Right Ans - Binding curve
Therapeutics that are large in size (biological polymers), have complex
structures, and are derived from natural sources. Right Ans - Biologics
A protective membrane barrier between the blood and the brain that consists
of endothelial cells joined by tight junctions and surrounded by astrocytes.
Right Ans - Blood-brain barrier
A concentration corresponding to half the maximal concentration of drug in
the bloodstream. Right Ans - C50
A therapy that involves introducing live cells into a patient. These cells can be
obtained from the patient or another individual, and may be modified
genetically or developmentally before use. Right Ans - Cell-based therapy
A protein found within a cell or cell membrane such as a receptor, an enzyme,
an ion channel, or a transporter. Right Ans - Cellular protein
The process of determining the biological, chemical, toxic, and
pharmacological properties of a compound during drug development.
Right Ans - Characterization (of a compound)
The volume of plasma cleared of a drug in a unit of time. Right Ans -
Clearance
The maximum concentration of drug achieved in the bloodstream. Right
Ans - Cmax
An antagonist that binds to a receptor, thereby inhibiting the binding of an
agonist to that receptor and preventing a molecular response from being
produced by the agonist. Right Ans - Competitive antagonist
Drug discovery that begins by identifying a compound. Right Ans -
Compound-centered drug discovery
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