Class notes
MBY 161 Antimicrobial Drugs Notes
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- University Of Pretoria (UP)
This is a comprehensive and detailed note on Antimicrobial Drugs for MBY 161. Essential!! To your success in academics!!
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Narrow spectrum antibiotic: a limited range of microbial types that can beANTIMICROBIAL DRUGS affected
THEME 6: CHAPTER 20 Broad spectrum antibiotic: a broad range of microbial types that can be
affected
1.1 MICROBIAL DRUGS: The selective toxicity of antibacterial action lies in the liposaccharide outer
Antibacterial drugs: drugs that interfere with the growth of microbes within the layer of gram+ bacteria and the porins that from water-filled channels across
host this layer
Paul Elrich: ‘magic bullet’ Salvarsan 1.4 THE ACTION OF ANTIMICROBIAL DRUGS:
Selective toxicity: killing harmful microbes without damaging the host
Chemotherapy: the use of drugs to treat a disease
Alexander Fleming: penicillin produced by Penicillium against other gram-
positive bacteria
Antibiotic: a substance produced by a microbe that, in small amounts, inhibits
another microbe
1.3 PROBLEMS WITH CHEMOTHERAPY: WHY ITS EASIER TO FIND
DRUGS AGAINST PROKARYOTES THAN EUKARYOTES:
Eukaryotes resemble host cells and the drugs ends up causing greater damage
with greater side effects
The viruses are inside the cell, it takes over the cell and controls the controls
the machinery of the host cell to make viruses rather than cellular material
Representative sources of antibiotics:
Bactericidal: they kill bacteria directly
, Bacteriostatic: inhibits bacterial growth(pathogen can grow back)
1.3 THE SPECTRUM OF ANTIMICROBIAL ACTIVITY:
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