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Hbss Sickle Cell Anemia Questions And Answers With Verified Solutions 100% Correct!!!
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Hbss Sickle Cell Anemia Questions AndAnswers With Verified Solutions 100%
Correct!!!
Clinical hallmarks of SCD - ANSWER✔✔ Vasooclusion and hemolysis
What are the atypical hemoglobin molecules called - ANSWER✔✔ Hemoglobin S
(HbS)
Definition of SCD - ANSWER✔✔ Complex group of autosomal recessive genetic
disorders associated with frequent and unpredictable crisis episodes
Normal adult Hgb contains how many alpha and beta chains - ANSWER✔✔ 2
alpha-globulin and 2 beta-globulin
A gene mutation in this subunit produces the HbS - ANSWER✔✔ Hemoglobin beta
subunit (HBB)
Hemoglobin S (HbS) is the abnormal version of what subunit - ANSWER✔✔ Beta-
globin
What is the gene mutation in HBB that produces HbS - ANSWER✔✔ Single
substitution of amino acid valine for glutamic acid at position 6 of the beta-
polypeptide chain
Differences between sickle cell trait and sickle cell disease - ANSWER✔✔ - Sickle
cell trait: heterozygous form
, - Sickle cell disease: homozygous
What is sickle cell trait? - ANSWER✔✔ The heterozygous form of SCD that is
asymptomatic
What is the acronym for sickle cell trait - ANSWER✔✔ HbAS (one normal HbA
gene and one abnormal HbS gene)
What is Sickle cell disease in comparison to sickle cell trait - ANSWER✔✔ There
are two HbS genes and no normal HbA genes
What is the acronym for sickle cell disease - ANSWER✔✔ HbSS (two abnormal
HbS genes and no normal HbA genes)
How many genotypes of SCD in the US? - ANSWER✔✔ 4
What are the 4 genotypes? - ANSWER✔✔ 1) Sickle Cell Anemia (HbSS)
2) Sickle Hemoglobin C (HbSC)
3) Two types of sickle-beta thalassemia (SB+ or SB° thalassemia)
What is the etiology of SCD? - ANSWER✔✔ Sickle cell hemoglobin S is transmitted
by an autosomal recessive gene
What is the etiology of SCD- who is it inherited from? - ANSWER✔✔ The parents
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