PMY 302 EXAM 1 DRUGS QUESTIONS WITH COMPLETE ANSWERS
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PMY 302 DRUGS
Institution
PMY 302 DRUGS
therefore, increase CO but doesn't change BP bc not much effect on B2
albuterol - B-AR agonist
Affinity: B2>>>> B1
Examples of drug/food- drug interactions in Type A ADRS - viagra and nitrates - severe
hypotension
warfarin and heparin - bleeding
alcohol and acetaminophen - increas...
PMY 302 EXAM 1 DRUGS
therefore, increase CO but doesn't change BP bc not much effect on B2
albuterol - B-AR agonist
Affinity: B2>>>> B1
Examples of drug/food- drug interactions in Type A ADRS - viagra and nitrates - severe
hypotension
warfarin and heparin - bleeding
alcohol and acetaminophen - increase CYP2E1 toxin
grapefruit - inhibits C450 which inc plasma drug conc
Benadryl vs Advil PM
minodoxil - treat hypertension but topically used for hair growth
loniten vs rogaine
Examples of Type A ADRs - sulbutamol- bronchi dilates in lungs at B2 but cause tachycardia on B1
in the heart
NSAID - reduces inflammation at COX2 but causes gastric ulcers at COX1
Acetaminophen- causes liver toxin CYP2E1- alcohol can increase this
Digoxin and erythromycin - cause increase in digoxin toxicity
Examples of Type B ADRs - Hypersensitivity- tinnitus after single aspirin pill
Idiosyncratic - giving sulfonamide to some G6PD deficient causes hemolysis
haloperidol - Type A ADRs , can cause tardive dyskinesia
, used for schizophrenia
Example of pharmacogenetics on Type A ADRs - polymorphism of N-acetyl transferase (NAT) - ADR
on pharmacokinetics example : slow acetylators causes decrease in hepatic elimination
Choline acetyl transferase - makes Ach
Phenylethanoamine N-methyltransferase - Make EPI from NE
commonality between somatic, PNS and SNS is: - first synapse uses Ach nicotinic receptors
pilocarpine - Muscarinic agonist - used in open angled glaucoma - causes miosis in the eye
echothiophate - AchE inhibitor used in open angled glaucoma
Ach IV : high vs low dose - high : will cause decrease in HR, BP and CO
low : will cause tachycardia - why?
diphenhydramine - suppress edema, pruritis and causes drowiness
At low dose, Ach has a higher affinity for M3 endothelial receptors. These cause an activation in NO
which will cause vasodilation thus decreasing BP. Then you will get a reflex to get tachycardia
cholinergic esters ( Ach muscarinic) agonist - Ach
methacholine
carbachol
bethanechol
oxotremorine
cevimeline
Bethanechol - pure muscarinic agonist , resistant to AchE because has a NH2+ group
carbachol - strong nicotinic agonist, resistant to AchE because has a NH2+ group.
drug use in glaucoma - muscarinic agonist -pilocarpine or carbachol
or
AchE inhibitor - physostigmine and organophosphate (echothiophate)
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