how do agonists binding to receptors alter cellular processes and cha/nge cellular phenotype -
alter expression level of protein and the turnover number of the enzyme
stereospecificity - most drugs are asymmetric (chiral or optically active); one stereoisomers binds
with much greater affinity to...
how do agonists binding to receptors alter cellular processes and cha/nge cellular phenotype -
alter expression level of protein and the turnover number of the enzyme
stereospecificity - most drugs are asymmetric (chiral or optically active); one stereoisomers binds
with much greater affinity to the specific receptor
pharmacology - study of all compounds that interact with the body
pharmacodynamics - what a drug does to the body. Includes the molecular mechanisms by which
a drug acts
pharmacokinetics - what the body does to a drug. Usually depends on the concentration at the
site of action
pharmacogenetics - responses to a drug as a consequence of genetic differences between
individuals
EC50 - Half maximal effective concentration. induces a response halfway between the baseline
and maximum after a specified exposure time. It is commonly used as a measure of drug's potency.
LD 50 - amount of an ingested substance that kills 50 percent of a test sample
phase 1 of biotransformation - makes drug slightly less hydrophobic
phase 2 of biotransformation - makes drug very hydrophillic
, drug - any agent that affects the living process, including chemicals that mimic or antagonize
endogenous
dose - amount of medication administered at single time (effects toxicity)
response - effect of a drug on the body, including both intended and unintended effects
therapeutic response - the desired effect
adverse effect - side effects
toxic response - any harmful repsonse
idiosyncratic response - individual hypersensitivity; happens on first dose
atropa belladona - dilates pupils
important that drug came from plant
Law of Mass Action - D + R <-- --> DR;
increasing the amount drug will cause greater amounts of drug receptor complexes to formed
the DR complex exerts the therapeutic response
saturability - a limited amount of receptors mediate the actions of a drug
reversbility - drugs bind to but then dissociate from their specific receptor
Agonist - a drug that binds to a receptor and mimics the effect of the endogenous ligand
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