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NU 214-1 PHARMACOKINETICS EXAM QUESTIONS WITH CORRECT ANSWERS
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NU 214-1 PHARMACOKINETICS EXAMQUESTIONS WITH CORRECT ANSWERS
What is Pharmacokinetics? - ANSWER The study of drug movement throughout
the body
What does 'pharmakon' mean? - ANSWER Medicine (drug) or poison
What does 'kinesis' mean? - ANSWER Motion
Pharmacokinetics is the motion of the medicine/drug ie. what the (body/drug) does
to the (body/drug). - ANSWER What the *body* does to the *drug*
What are 4 stages of Pharmacokinetics? - ANSWER 1. Absorption
2. Distribution
3. Metabolism
4. Excretion
*Absorption* - ANSWER
Absorption is when... - ANSWER The drug enters the blood stream
Bioavailability describes what? - ANSWER The degree to which the drug is
absorbed and transported to the blood
The percent of a drug that is available to produce the effect
Note: - ANSWER Bioavailability is important because a drug that is absorbed in
the intestine must pass through the liver before it reaches systemic circulation.
Therefore when the liver filters it, it's important there is still enough of a percentage
left to produce the desired affect
*the more that is broken down, the less we have to use
, What is a bioequivalent? - ANSWER 2 drugs with the same bioavailability
The initial metabolism in the liver of the drug is called? - ANSWER The hepatic
First Pass Effect
Drug with a *high* first pass effect are given by routes other than... - ANSWER
Oral
So oral drugs and IV drugs are going to be (smaller/larger) because why? -
ANSWER Smaller because they bypass the hepatic first pass effect
*its a lower dosage because nothing is going to have been broken down
Name routes that are used for First-Pass drugs. - ANSWER -Hepatic arterial
-Oral
-Portal venous
-Rectal
Name some of the routes that are used for Non-First Pass drugs. - ANSWER -Aural
(instilled into the ear)
-Buccal
-Inhaled
-Intraarterial
-Intramuscular
-Intranasal
-Intraocular
-Intravaginal
-Intravenous
-Subcutaneous
-Sublingual
-Transdermal
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