Summary
Summary of the serotnergic pathway under all different conditions
- Institution
- University Of The Freestate (UFS)
Summary of the serotnergic pathway under all different conditions
[Show more]
Content preview
In your own words, explain how synaptic communication by the Serotonin neurotransmitter worksin an individual with a normal functioning system. Discuss the different components involved by
referring to contributing genes and functionality.
Serotonin (5-Hydroxytryptamine) is present in vesicles within the presynaptic neuron. Stimulus
causes the release (via exocytosis) of the serotonin into the synaptic cleft. Serotonin can then bind to
the heteroreceptors HTR2A (5-Hydroxytryptamine receptor 2A) on the postsynaptic neuron, which
passes the message along (signal transduction). Serotonin can also bind to the autoreceptors HTR1B
on the presynaptic neuron, signalling the cell to stop exocytosis and thereby inhibiting the message.
Excess serotonin is taken back up by SERT (Serotonin Transporter) into the presynaptic neuron and
put back into the vesicles (revesiculation) by the proton pump VMAT2 (Vesicular Monoamine
Transporter 2) to be used again or serotonin is reuptaken in the glia cell by SERT and broken down
(metabolised) by MAOA (Monoamine Oxidase A).
In your own words, explain how synaptic communication by the Serotonin neurotransmitter works
in an individual with an abnormal functioning system. Discuss the different components involved
by referring to contributing genes and functionality.
Serotonin (5-Hydroxytryptamine) is present in vesicles within the presynaptic neuron. Stimulus
causes the release (via exocytosis) of the serotonin into the synaptic cleft. In a normal functioning
system, serotonin can then bind to the heteroreceptors HTR2A (5-Hydroxytryptamine receptor 2A)
on the postsynaptic neuron, which passes the message along (signal transduction). Serotonin can
also bind to the autoreceptors HTR1B on the presynaptic neuron, signalling the cell to stop
exocytosis and thereby inhibiting the message. In a system where there is an excess of transporters
(LL genotype at the HTTLPR polymorphic region) these two steps do not occur, only the following
two steps occur (they also occur in a normal functioning system).
Excess serotonin is taken back up by SERT (Serotonin Transporter) into the presynaptic neuron and
put back into the vesicles (revesiculation) by the proton pump VMAT2 (Vesicular Monoamine
Transporter 2) to be used again or serotonin is reuptaken in the glia cell by SERT and broken down
(metabolised) by MAOA (Monoamine Oxidase A).
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through EFT, credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying this summary from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller charneb1. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy this summary for R70,00. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
64438 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy summaries for 14 years now