• Natural or synthetic substances that produce physiological changes when taken into
the body.
• Not all substances that produce physiological changes are drugs
- Many drugs have psychoactive effects, i.e., produce changes in: Mood, Cognition
Experience
- They influence behaviour by altering activity at nervous system synapses.
Why do psychologists care about drugs?
- Introduce drugs to manipulate the activity of particular NTs.
- Note: NT =Neurotransmitter
- Examine effects on cognition
- Investigates biological basis of cognition.
- Many people use a drug of some type almost on a daily basis. E.g. Caffeine
How do drugs influence cognitive performance?
Why do people love drugs?
How drugs affect the nervous system: Action Potential
Drugs act on our synapses.
Synapses = A very narrow gap of about 20nm between neurons
NB
- NT made in presynaptic neuron stored in synaptic vesicles
- Post-synaptic neuron membrane Neuroreceptors.
- Agonist = Increases NT effect
- Antagonist = Reduces NT effect
Cholinergic Synapse
, Pre-synaptic neuron
Post-synaptic neuron
- Synapses with the NT acetylcholine = cholinergic synapses.
- Action potential arrives at presynaptic membrane.
- Voltage-gated calcium channels open calcium ions enter the presynaptic neuron.
Cholinergic Synapse
• Ions in synaptic vesicles fuse with the presynaptic membrane, releasing acetylcholine
into the synaptic cleft.
• Acetylcholine diffuses across the synaptic cleft and binds to specific neuroreceptor
sites in the post synaptic membrane.
• Sodium channels open.
• Sodium ions diffuse into the postsynaptic membrane causing depolarisation, which
may cause an action potential
• Acetylcholinesterase breaks down acetylcholine.
• The products diffuse back into the presynaptic neuron.
• Here, acetylcholine is resynthesised using adenosine -triphosphate (ATP) from the
mitochondria.
Drugs can alter:
Pre-synaptic events
E.g.
• Processes in axon
• NT synthesis
• NT storage
• NT release
Synaptic cleft or post-synaptic events
E.g.
• Inactivation/re-uptake mechanism
• Activation of receptor molecules
• Activity of second-messenger systems
The Dopaminergic Reward System
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